MULTIGENERATION STUDY OF FD-BLUE AND C-BLUE NO-2 IN RATS
MULTIGENERATION STUDY OF FD-BLUE AND C-BLUE NO-2 IN RATS
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DOI：
10.1016/0278-6915(86)90351-0
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发表时间：
1986-02-01
影响因子：
4.3
通讯作者：
WAZETER, FX
中科院分区：
文献类型：
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作者：
BORZELLECA, JF;GOLDENTHAL, EI;WAZETER, FX
在一项三代生殖研究中，对10只雄性和20只雌性Charles River CD大鼠的组喂食FD & C Blue No. 2，膳食摄入量为0.0、2.5、25、75和250 mg/kg体重/天。在250 mg/kg/天剂量水平的大鼠中观察到浅蓝色被毛，在75和250 mg/kg/天剂量组的大鼠中观察到蓝绿色粪便。对照组和给药组所有窝仔的妊娠、活力和泌乳指数相当。对于F2窝，2.5和25 mg/kg/天剂量组雌性大鼠的生育力指数显著低于对照组雌性。然而，两个较高剂量水平下F2窝的雌性生育力指数未降低，任何剂量水平下F1和F3窝的雌性生育力指数也未降低。尽管F2和F2窝中某些组雄性大鼠的生育力指数降低，但认为这些变化与化合物无关。对妊娠第19天处死的所有F2c和F3幼仔母鼠的卵巢和子宫进行检查，未发现大体解剖学异常。在研究期间死产幼仔或死亡幼仔中未观察到异常变化。在处死和尸检的任何F1或F3大鼠中均未观察到化合物相关的大体或显微镜病理学病变，并且在F1亲代大鼠中未记录到化合物相关的器官重量变化。
In a three-generation reproduction study, groups of ten male and 20 female Charles River CD rats were fed FD & C Blue No. 2 at dietary levels providing intakes of 0.0, 2.5, 25, 75 and 250 mg/kg body weight/day. Slightly bluish-coloured fur was noted in rats at the 250-mg/kg/day dose level and bluish-green-coloured faeces were produced by rats in the 75- and 250-mg/kg/day groups. The gestation, viability and lactation indices of all litters were comparable for the control and treated groups. The fertility indices for female rats in the 2.5- and 25-mg/kg/day groups were significantly lower than those for control females in the case of the F2litters. However, there was no reduction in the female fertility indices for the F2litters at the two higher dosage levels, nor for the F1and F3litters at any dosage level. Although fertility indices were reduced for some groups of male rats in the F2band F2clitters, these changes were not considered to be compound-related. Examination of the ovaries and uteri of all dams killed on day 19 of gestation of the F2cand F3clitters revealed no gross anatomical abnormalities. No unusual changes were observed in the stillborn pups or in pups dying during the study. There were no compound-related gross or microscopic pathological lesions in any of the F1or F3arats that were killed and necropsied, and no compound-related organ-weight variations were recorded in the F1parental rats.