The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients
The IFNL3/4 ΔG variant increases susceptibility to cytomegalovirus retinitis among HIV-infected patients
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DOI：
10.1097/qad.0000000000000379
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发表时间：
2014-08-24
期刊：
影响因子：
3.8
通讯作者：
Bochud, Pierre-Yves
中科院分区：
文献类型：
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作者：
Bibert, Stephanie;Wojtowicz, Agnieszka;Bochud, Pierre-Yves
背景：巨细胞病毒（CMV）视网膜炎是HIV感染不受控制的患者视力受损和失明的主要原因。而干扰素λ 3的多态性（IFNL 3，以前命名为IL 28 B）强烈影响丙型肝炎的临床过程，很少有研究检查这种多态性在丙型肝炎病毒以外的病毒感染中的作用。目的：分析新发现的IFNL 3/4变异rs368234815与HIV相关性视网膜炎易感性的关系，设计和方法：这项回顾性纵向研究包括来自瑞士HIV队列研究的4884名白色患者，其中1134名患者有发生CMV视网膜炎的风险（CD 4（+）最低点）。
Background: Cytomegalovirus (CMV) retinitis is a major cause of visual impairment and blindness among patients with uncontrolled HIV infections. Whereas polymorphisms in interferon-lambda 3 (IFNL3, previously named IL28B) strongly influence the clinical course of hepatitis C, few studies examined the role of such polymorphisms in infections due to viruses other than hepatitis C virus.Objectives: To analyze the association of newly identified IFNL3/4 variant rs368234815 with susceptibility to CMV-associated retinitis in a cohort of HIV-infected patients.Design and methods: This retrospective longitudinal study included 4884 white patients from the Swiss HIV Cohort Study, among whom 1134 were at risk to develop CMV retinitis (CD4(+) nadir