A Range of Cancers Is Associated with the rs6983267 Marker on Chromosome 8
A Range of Cancers Is Associated with the rs6983267 Marker on Chromosome 8
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DOI：
10.1158/0008-5472.can-08-1838
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发表时间：
2008-12-01
期刊：
影响因子：
11.2
通讯作者：
Cybulski, Cezary
中科院分区：
文献类型：
--
作者：
Wokolorczyk, Dominika;Gliniewicz, Bartlomiej;Cybulski, Cezary
对常见癌症的几次全基因组搜索已经发现了少数携带低风险癌症易感性标志物的基因座。染色体8 q24上的一个标记rs6983267与结肠癌和前列腺癌有关，因此是多癌易感性标记的良好候选者。为了确定与rs6983267相关的癌症部位的范围，我们对7,665例癌症病例（代表11个常见癌症部位）和1,910例对照进行了基因分型。GG基因型携带者患前列腺癌的优势比（OR）显著[OR，1.77; 95%可信区间（CI），1.47-2.13]。Gleason评分为8 - 10的肿瘤的纯合子OR（OR，1.94; 95%CI，1.18-3.20）高于Gleason评分为7及以下的肿瘤（OR，1.65; 95%CI，1.31-2.08）。显著升高在其他4个癌症部位观察到（纯合子）OR，包括结肠（OR，1.36; 95%CI，1.08-1.72）、肾脏（OR，1.52; 95%CI，1.12-2.05）、甲状腺（OR，1.37; 95%CI，1.02-1.82）和喉（OR，1.39; 95%CI，1.02-1.90）。有8个地点的癌症家族史信息可用。对于8个位点中的6个（前列腺、乳腺、膀胱、喉、肺和肾），具有阳性家族史（至少一个一级癌症）的病例的纯合子OR高于具有未受影响的一级亲属的病例。我们的研究结果表明，与rs6983267标记物相关的癌症范围可能比以前认为的要大。[Cancer Res 2008;68（23）：9982-6]
Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker. To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls. A significant odds ratio (OR) was observed for prostate cancer for carriers of genotype GG [OR, 1.77; 95% confidence interval (CI), 1.47-2.13]. The homozygote OR was higher for tumors with Gleason score 8 to 10 (OR, 1.94; 95% CI, 1.18-3.20) than for tumors with Gleason score 7 and below (OR, 1.65; 95% CI, 1.31-2.08). Significantly elevated (homozygote) ORs were observed for 4 other cancer sites, including colon (OR, 1.36; 95% CI, 1.08-1.72), kidney (OR, 1.52; 95% CI, 1.12-2.05), thyroid (OR, 1.37; 95% CI, 1.02-1.82), and larynx (OR, 1.39; 95% Cl, 1.02-1.90). Information was available on family histories of cancer for eight sites. For six of the eight sites (prostate, breast, bladder, larynx, lung, and kidney), the homozygote ORs were higher for cases with a positive family history (at least one first-degree with any cancer) than for cases with unaffected first-degree relatives. Our results suggest that the range of cancers associated with the rs6983267 marker might be larger than previously thought. [Cancer Res 2008;68(23):9982-6)]