Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis:: results from a double-blind, randomized study
Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis:: results from a double-blind, randomized study
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DOI：
10.1016/s0167-8140(01)00327-9
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发表时间：
2001-06-01
影响因子：
5.7
通讯作者：
Bergh, J
中科院分区：
文献类型：
--
作者：
Boström, Å;Lindman, H;Bergh, J
目的：放射性皮炎是放射治疗中一种非常常见的副作用。可能需要中断治疗。对于这种情况，大量缺乏循证治疗方法。本研究的目的是在一项前瞻性、双盲、随机研究中调查糠酸莫米松乳膏（MMF）对放射性皮炎的影响。材料和方法：本研究纳入49例淋巴结阴性乳腺癌患者。手术行扇形切除，术后用相同辐射质量和剂量的光子对乳腺实质进行放射治疗。患者随机接受MMF或润肤霜治疗。从放疗开始至第12段（24 Gy），每周2次涂抹于被照射皮肤上，此后每天1次，直至放疗完成后3周。两组患者每天均使用非盲性润肤霜。急性放射性皮炎的强度每周评估一次红斑和色素沉着，使用反射分光光度计和皮肤反应的视觉评分。结果：MMF联合润肤膏治疗急性放射性皮炎与单独使用润肤膏相比，疗效显著（P = 0.0033）。两组患者的色素沉着无明显差异。结论：在润肤霜中加入MMF（一种有效的外用皮质类固醇）在减轻急性放射性皮炎方面比单独使用润肤霜更有效。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Purpose: Radiation-induced dermatitis is a very common side effect of radiation therapy. and may necessitate interruption of the therapy. There is a substantial lack of evidence-based treatments for this condition. The aim of this study was to investigate the effect of mometasone furoate cream (MMF) on radiation dermatitis in a prospective, double-blind, randomized study.Material and methods: The study comprised 49 patients with node-negative breast cancer. They were operated on with sector resection and scheduled for postoperative radiotherapy using photons with identical radiation qualities and dosage to the breast parenchyma. The patients were randomized to receive either MMF or emollient cream. The cream was applied on the irradiated skin twice a week from the start of radiotherapy until the 12th fraction (24 Gy) and thereafter once daily until 3 weeks after completion of radiation. Both groups additionally received non-blinded emollient cream daily. The intensity of the acute radiation dermatitis was evaluated on a weekly basis regarding erythema and pigmentation, using a reflectance spectrophotometer together with visual scoring of the skin reactions.Results: MMF in combination with emollient cream treatment significantly decreased acute radiation dermatitis (P = 0.0033) compared with emollient cream alone. There was no significant difference in pigmentation between the two groups.Conclusions: Adding MMF, a potent topical corticosteroid, to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.