Resting-state functional MRI: Functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients
Resting-state functional MRI: Functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients
复制标题
静息态功能 MRI：原发性开角型青光眼患者视觉皮层的功能连接分析
DOI：
10.1002/hbm.22079
复制
发表时间：
2013-10-01
影响因子：
4.8
通讯作者：
Li, Yonggang
中科院分区：
文献类型：
--
作者：
Dai, Hui;Morelli, John N.;Li, Yonggang
目的：应用静息状态功能磁共振成像技术分析人类原发性开角型青光眼(POAG)患者视皮质的功能连通性。材料和方法：22名已知的POAG患者和22名年龄匹配的对照纳入这项IRB批准的研究。受试者接受3T磁共振检查，使用静息状态血氧水平依赖和三维脑体积成像(3D-Bravo)MRI。用标准软件进行数据处理。FC图以体素方式从Brodmann Areas(BA)17/18/19/7生成。结果：体素分析显示POAG组初级视皮层(BA17)与右下颞叶、左侧梭形回、左侧枕中回、右侧枕上回、左侧中央后回、右侧中央前回和左侧小脑前叶之间的FC降低。BA17与左侧小脑、右侧小脑中脚、右侧额中回和核外回之间的FC增加(P<；0.05)。在较高的视皮层(BA18/19)，Fc阳性表达消失于小脑疣、右侧颞中回和右侧颞上回(P<；0.05)。BA18/19与右侧岛状回之间的Fc负值消失(P<；0.05)。感兴趣区分析显示，与对照组相比，POAG患者之间的FC差异无统计学意义(P>；0.05)。结论：POAG患者存在视皮层Fc的改变。这些变化包括视觉皮质和相关视觉区域之间的连接改变，以及初级和高级视觉区域之间的连接中断。Hum Brain Mapp 34：2455-2463,2013。(C)2012年威利期刊公司。
Purpose: To analyze functional connectivity (FC) of the visual cortex using resting-state functional MRI in human primary open-angle glaucoma (POAG) patients. Materials and Methods: Twenty-two patients with known POAG and 22 age-matched controls were included in this IRB-approved study. Subjects were evaluated by 3 T MR using resting-state blood oxygenation level dependent and three-dimensional brain volume imaging (3D-BRAVO) MRI. Data processing was performed with standard software. FC maps were generated from Brodmann areas (BA) 17/18/19/7 in a voxel-wise fashion. Region of interest analysis was used to specifically examine FC among each pair of BA17/18/19/7. Results: Voxel-wise analyses demonstrated decreased FC in the POAG group between the primary visual cortex (BA17) and the right inferior temporal, left fusiform, left middle occipital, right superior occipital, left postcentral, right precentral gyri, and anterior lobe of the left cerebellum. Increased FC was found between BA17 and the left cerebellum, right middle cerebellar peduncle, right middle frontal gyrus, and extra-nuclear gyrus (P < 0.05). In terms of the higher visual cortices (BA18/19), positive FC was disappeared with the cerebellar vermis, right middle temporal, and right superior temporal gyri (P < 0.05). Negative FC was disappeared between BA18/19 and the right insular gyrus (P < 0.05). Region of interest analysis demonstrated no statistically significant differences in FC between the POAG patients relative to the controls (P > 0.05). Conclusion: Changes in FC of the visual cortex are found in patients with POAG. These include alterations in connectivity between the visual cortex and associative visual areas along with disrupted connectivity between the primary and higher visual areas. Hum Brain Mapp 34:2455-2463, 2013. (c) 2012 Wiley Periodicals, Inc.