Age of Menarche in a Longitudinal US Cohort
Age of Menarche in a Longitudinal US Cohort
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DOI：
10.1016/j.jpag.2018.05.002
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发表时间：
2018-08-01
影响因子：
1.8
通讯作者：
Teitelbaum, Susan L.
中科院分区：
文献类型：
--
作者：
Biro, Frank M.;Pajak, Ashley;Teitelbaum, Susan L.
研究目的：月经初潮是女性生命中的一个重要里程碑，历史上已经使用几种方法确定。本研究的目的是：（1）确定在月经初潮的年龄从多个报告的父母和青少年参与者在一项前瞻性研究;（2）检查影响月经初潮年龄的因素;（3）确定相关的月经初潮和青春期tempers.Design：纵向观察研究。干预措施和主要结果测量：父母和参与者报告初潮年龄和青春期克里思。父母报告和参与者报告之间的相关性很高（斯皮尔曼R = 0.799，P <0.001），差异不显著。总体初潮的中位年龄为12.25岁。与黑人参与者相比，西班牙裔女孩更有可能初潮早，而白色和亚洲女孩更有可能初潮晚。初潮年龄与乳房发育年龄高度相关（斯皮尔曼R = 0.547; P <0.001），与体重指数呈负相关（斯皮尔曼R = -0.403; P <0.001）。乳房发育早者的克里思（乳房发育至月经初潮的年龄间隔）较慢。结论：父母和青少年的月经初潮报告高度相关。乳房发育较早与青春期克里思较慢有关。体重指数对初潮年龄的影响大于种族和民族。
Study Objective: Menarche is a critical milestone in a woman's life, and historically has been determined using several approaches. The goals of this study were to: (1) determine age at menarche from multiple reports of parents and adolescent participants in a prospective study; (2) examine factors affecting age at menarche; and (3) determine correlates of menarche and pubertal tempo.Design: Longitudinal observational study.Setting: Three sites of the Breast Cancer and the Environment Research Program.Participants: Girls enrolled at 6-8 years of age. Interventions andMain Outcome Measures: Parental and participant reported age of menarche, and tempo of puberty.Results: There were 946 girls who were assigned an age of menarche. The correlation between parent and participant reports was high (Spearman R = 0.799, P < .001), and the difference was insignificant. Median age at menarche overall was 12.25 years. Compared with black participants, Hispanic girls were more likely to have menarche earlier, whereas white and Asian girls were more likely to have menarche later. Age of menarche was highly correlated with age of breast development (Spearman R = 0.547; P < .001), and inversely with body mass index (Spearman R = -0.403; P < .001). Tempo (interval of age of breast development to menarche) was slower in those with earlier breast development.Conclusion: Parental and adolescent reports of menarche are highly correlated. Earlier breast maturation was associated with slower tempo through puberty. Body mass index had a greater effect on age at menarche than did race and ethnicity.