Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis.
Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis.
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可溶性 CD30 升高是丙型肝炎病毒诱导的同种异体移植肝硬化患者的特征。
DOI：
10.1097/01.tp.0000295973.31877.7b
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发表时间：
2007
期刊：
影响因子：
6.2
通讯作者：
Mohanakumar,Thalachallour
中科院分区：
文献类型：
--
作者：
Bharat,Ankit;Narayanan,Kishore;Golocheikine,Anjali;Steward,Nancy;Crippin,Jeffrey;Lisker-Melman,Mauricio;Shenoy,Surendra;Lowell,Jeffrey;Chapman,WilliamC;Mohanakumar,Thalachallour
Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) significantly accelerates progression to allograft cirrhosis. Current biochemical parameters to monitor progression of chronic HCV after OLT have yielded low specificity and sensitivity. Here we investigated the HCV-specific immunity and serum levels of soluble CD30 (sCD30), a novel marker of Th2 immunity, in patients with and without allograft cirrhosis. Patients with hepatic inflammation but no cirrhosis (HIN, n= 20) revealed elevated serum interferon (IFN)-γ and high frequency of IFN-γ producing CD4+ T (h1) cells compared to those with hepatic cirrhosis (HFC, n= 20) that had high interleukin (IL)-5 and IL-5 producing CD4+ T (h2) cells. Patients with HFC, but not HIN, were found to have significantly higher levels of sCD30. Therefore, we conclude that lack of optimal Th1-type CD4+ T cells is associated with HCV-induced allograft cirrhosis. Further, sCD30 may represent a novel marker for surveillance of hepatic cirrhosis in transplant recipients with chronic HCV infection.
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影响因子：
1.5
作者：
Pellegrini, P;Berghella, AM;Adorno, D
通讯作者：
Adorno, D
慢性丙型肝炎感染患者和健康抗丙型肝炎病毒阳性无病毒献血者中 T 细胞和 B 细胞对不同丙型肝炎病毒抗原的反应
影响因子：
13.5
作者：
M. Lechmann;H. Ihlenfeldt;I. Braunschweiger;G. Giers;G. Jung;B. Matz;R. Kaiser;Tilman Sauerbruch;U. Spengler
通讯作者：
U. Spengler
慢性丙型肝炎感染患者和健康的抗丙型肝炎病毒阳性无病毒血症的献血者中，T 细胞和 B 细胞对不同丙型肝炎病毒抗原的反应。
影响因子：
13.5
作者：
M. Lechmann;H. Ihlenfeldt;I. Braunschweiger;G. Giers;G. Jung;Bertfried Matz;R. Kaiser;Tilman Sauerbruch;U. Spengler
通讯作者：
U. Spengler
影响因子：
13.5
作者：
C. Féray;M. Gigou;D. Samuel;V. Paradis;J. Wilber;Marie France David;M. Urdea;M. Reynés;C. Bréchot;H. Bismuth
通讯作者：
H. Bismuth
影响因子：
13.5
作者：
Garcia-Retortillo, M;Forns, X;Rodes, J
通讯作者：
Rodes, J