Quorum sensing in the squid-Vibrio symbiosis.
Quorum sensing in the squid-Vibrio symbiosis.
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DOI：
10.3390/ijms140816386
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发表时间：
2013-08-07
影响因子：
5.6
通讯作者：
Miyashiro T
中科院分区：
文献类型：
--
作者：
Verma SC;Miyashiro T
群体感应是细菌用来协调群体行为的一种细胞间通讯形式，如生物膜形成、抗生素和毒力因子的产生。群体感应一词最初是用来描述海洋细菌费氏弧菌（Vibrio fischeri）培养物中发光产生的机制。发光和更普遍的群体感应对于V. fischeri与夏威夷短尾鱿鱼Euprymna spectopes形成互利共生关系很重要。当V.fischeri细胞通过鞭毛运动从周围的海水迁移到幼年鱿鱼的一个称为光器官的特殊结构时，共生关系就建立起来了。细胞在光器官内生长到高细胞密度，其中感染在动物的一生中持续。一个成功的共生的标志是由V. fischeri产生的发光，通过消除其在水柱中的阴影，在夜间使鱿鱼发光。虽然管理群体感应的调节网络对于适当调节鱿鱼光器官内的V. fischeri发光至关重要，但它们也调节共生过程中的发光独立过程。在这篇综述中，我们讨论了群体感应网络的V. fischeri和强调其在不同阶段的影响在主机殖民。
Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures of the marine bacterium Vibrio fischeri. Luminescence and, more generally, quorum sensing are important for V. fischeri to form a mutualistic symbiosis with the Hawaiian bobtail squid, Euprymna scolopes. The symbiosis is established when V. fischeri cells migrate via flagella-based motility from the surrounding seawater into a specialized structure injuvenile squid called the light organ. The cells grow to high cell densities within the light organ where the infection persists over the lifetime of the animal. A hallmark of a successful symbiosis is the luminescence produced by V. fischeri that camouflages the squid at night by eliminating its shadow within the water column. While the regulatory networks governing quorum sensing are critical for properly regulating V. fischeri luminescence within the squid light organ, they also regulate luminescence-independent processes during symbiosis. In this review, we discuss the quorum-sensing network of V. fischeri and highlight its impact at various stages during host colonization.
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