Poly(HDDA)-Based Polymers for Microfabrication and Mechanobiology
Poly(HDDA)-Based Polymers for Microfabrication and Mechanobiology
复制标题
DOI：
10.1557/adv.2017.57
复制
发表时间：
2017-01-01
期刊：
影响因子：
0.8
通讯作者：
Van Vliet, Krystyn J.
中科院分区：
文献类型：
--
作者：
Espinosa-Hoyos, Daniela;Du, Huifeng;Van Vliet, Krystyn J.
材料加工和增材制造为生物医学研究提供了令人兴奋的机会，包括细胞-材料相互作用的研究。然而，一些最有效的微加工材料并不完全适用于生物应用，需要大量的后处理或表现出高的机械刚度，限制了应用范围。相反，表现出高细胞相容性和低刚度的材料需要长的处理时间，通常具有降低的特征空间分辨率。在这里，我们研究了使用己二醇二丙烯酸酯（HDDA），一个经典的和有效的聚合物立体光刻，少突胶质细胞祖细胞（OPC）的文化。我们开发了复合HDDA-聚乙二醇丙烯酸酯水凝胶，其在肌肉组织的范围内表现出高生物相容性、机械刚度和在类似于5 μ m分辨率下的高打印效率。
Materials processing and additive manufacturing afford exciting opportunities in biomedical research, including the study of cell-material interactions. However, some of the most efficient materials for microfabrication are not wholly suitable for biological applications, require extensive post-processing or exhibit high mechanical stiffness that limits the range of applications. Conversely, materials exhibiting high cytocompatibility and low stiffness require long processing times with typically decreased spatial resolution of features. Here, we investigated the use of hexanediol diacrylate (HDDA), a classic and efficient polymer for stereolithography, for oligodendrocyte progenitor cell (OPC) culture. We developed composite HDDA-polyethylene glycol acrylate hydrogels that exhibited high biocompatibility, mechanical stiffness in the range of muscle tissue, and high printing efficiency at similar to 5 mu m resolution.