Reduction of cerebellar grey matter in Crus I and II in schizophrenia
Reduction of cerebellar grey matter in Crus I and II in schizophrenia
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DOI：
10.1007/s00429-011-0365-2
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Gallinat, Juergen
中科院分区：
文献类型：
--
作者：
Kuehn, Simone;Romanowski, Alexander;Gallinat, Juergen
小脑结构缺陷与精神分裂症有关。虽然一些基于感兴趣区的研究表明小脑体积存在偏差，但传统的基于全脑体素的形态计量学(VBM)研究的荟萃分析并不表明小脑存在异常。由于这种差异可能是由于VBM的方法学问题，我们使用了小脑优化的VBM程序。我们获得了29名精神分裂症患者和45名健康对照的高分辨率MRI扫描，并使用了利用空间无偏幕下工具箱的VBM方法(Diedrichsen in NeuroImage 33：127-138,2006)。与健康对照组相比，精神分裂症患者左侧小脑小脑I/II区灰质体积减少，这与思维障碍(P<；0.05；单侧)和在连线测验B中的表现(P<；0.01)有关。常规全脑VBM检查未发现小脑组差异。小脑分析的结果为精神分裂症患者位于CRU I/II的明显灰质缺陷提供了证据。这一区域与思维障碍和轨迹形成能力的关联支持了先前提出的小脑在精神分裂症包括思维障碍的心理过程中的协调作用。传统的VBM未能检测到这种影响，这表明以前的研究可能低估了小脑结构缺陷在精神分裂症中的重要性。
Structural deficiencies within the cerebellum have been associated with schizophrenia. Whereas several region-of-interest-based studies have shown deviations in cerebellar volume, meta-analyses on conventional whole-brain voxel-based morphometry (VBM) studies do not implicate abnormalities in the cerebellum. Since this discrepancy could be due to methodological problems of VBM, we used a cerebellum-optimized VBM procedure. We acquired high-resolution MRI scans from 29 schizophrenia patients and 45 healthy controls and used a VBM approach utilizing the Spatially Unbiased Infratentorial toolbox (Diedrichsen in Neuroimage 33:127-138, 2006). Relative to healthy controls, schizophrenia patients showed reductions of grey matter volume in the left cerebellum Crus I/II that were correlated with thought disorder (p < 0.05; one-sided) and performance in the Trail-making test B (p < 0.01). No cerebellar group differences were detected employing conventional whole-brain VBM. The results derived from the cerebellum analysis provide evidence for distinct grey matter deficits in schizophrenia located in Crus I/II. The association of this area with thought disorder and Trail-making performance supports the previously suggested role of the cerebellum in coordination of mental processes including disordered thought in schizophrenia. The failure of conventional VBM to detect such effects suggests that previous studies might have underestimated the importance of cerebellar structural deficits in schizophrenia.