Intra-individual variation of analytes in serum from patients with chronic liver diseases.
Intra-individual variation of analytes in serum from patients with chronic liver diseases.
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DOI：
10.1093/clinchem/33.7.1133
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发表时间：
1987-07
影响因子：
9.3
通讯作者：
W. Hölzel
中科院分区：
文献类型：
--
作者：
W. Hölzel
20例慢性肝病（CLD）患者在稳定期内14种分析物的平均生物学个体内CV在Na+、K+、Cl-、总蛋白、白蛋白、胆碱酯酶、血红蛋白和α-淀粉酶的情况下显著高于正常组;胆固醇、碱性磷酸酶、天冬氨酸氨基转移酶和丙氨酸氨基肽酶与正常组无显著差异;谷丙转氨酶和γ-谷氨酰转移酶明显低于正常组。CLD患者的平均个体内变异没有显著的性别相关差异。所有分析物（包括酶）的个体值均呈高斯分布。个体内变异的估计生物学成分和每个实验室确定的分析变异可用于推导监测CLD的决策标准。
The average biological intra-individual CV in 20 patients with chronic liver diseases (CLD), estimated for 14 analytes during a stationary phase, significantly exceeded that for a normal group in the cases of Na+, K+, Cl-, total protein, albumin, cholinesterase, hemoglobin, and alpha-amylase; it did not differ significantly from the normal group for cholesterol, alkaline phosphatase, aspartate aminotransferase, and alanine aminopeptidase; and it was significantly lower than in the normal group for alanine aminotransferase and gamma-glutamyltransferase. There were no significant sex-related differences in mean intra-individual variation in CLD patients. Individual values were gaussian-distributed for all analytes, including enzymes. The estimated biological component of intra-individual variation and the analytical variation as determined for each laboratory can be used to derive decision-making criteria in monitoring CLD.