Evaluation of the 11CO2 Positron Emission Tomographic Method for Measuring Brain pH. I. pH Changes Measured in States of Altered PCO2
Evaluation of the 11CO2 Positron Emission Tomographic Method for Measuring Brain pH. I. pH Changes Measured in States of Altered PCO2
复制标题
11CO2 正电子发射断层扫描方法测量脑 pH 值的评估。
DOI：
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发表时间：
1987
影响因子：
6.3
通讯作者：
R. Ackerman
中科院分区：
文献类型：
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作者：
R. Buxton;N. Alpert;V. Babikian;S. Weise;J. Correia;R. Ackerman
用正电子发射断层扫描（PET）测量局部脑pH的11 CO2方法已进行了实验评估，测试了动力学模型的充分性和该方法测量脑pH变化的能力。在连续吸入11 CO2期间和之后测量的血浆和组织时间/活动曲线与动力学模型拟合，该模型包括组织pH，血流量，以及将CO2固定成除溶解气体和碳酸氢根离子以外的化合物。对于十只狗中的每一只，使用PET在两个PaCO 2值（范围21-67 mm Hg）下测量大脑pH值。动力学模型在吸入和洗脱标签期间均很好地拟合数据，模型与测量值的剩余均方根（RMS）偏差与PET数据的统计质量一致。从PET数据计算的脑pH值显示出与log（PaCO 2）的线性变化。这些结果与先前报道的脑pH值测量结果非常一致，无论是绝对值还是随PCO 2的变化。这些pH值在正常和病理状态的解释进行了讨论。
The 11CO2 method for measuring local brain pH with positron emission tomography (PET) has been experimentally evaluated, testing the adequacy of the kinetic model and the ability of the method to measure changes in brain pH. Plasma and tissue time/activity curves measured during and following continuous inhalation of 11CO2 were fit with a kinetic model that includes effects of tissue pH, blood flow, and fixation of CO2 into compounds other than dissolved gas and bicarbonate ions. For each of ten dogs, brain pH was measured with PET at two values of PaCO2 (range 21–67 mm Hg). The kinetic model fit the data well during both inhalation and washout of the label, with residual root mean square (RMS) deviations of the model from the measurements consistent with the statistical quality of the PET data. Brain pH calculated from the PET data shows a linear variation with log(PaCO2). These results were in good agreement with previously reported measurements of brain pH, both in absolute value and in variation with PCO2. The interpretation of these pH values in normal and pathological states is discussed.