Body mass index and asthma severity in the National Asthma Survey
Body mass index and asthma severity in the National Asthma Survey
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DOI：
10.1136/thx.2007.082784
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发表时间：
2008-01-01
期刊：
影响因子：
10
通讯作者：
Holguin, F.
中科院分区：
文献类型：
--
作者：
Taylor, B.;Mannino, D.;Holguin, F.
背景资料：肥胖和哮喘严重程度之间的关联仍然存在争议，并仅限于小型study.Methods：我们确定了身体质量指数（BMI）和哮喘严重程度在全国哮喘调查的关联。我们纳入了在过去5年中自我报告哮喘症状的成人（年龄≥ 18岁）。共3095例患者分为以下BMI类别：1080例（35%）非超重（BMI 25），993例（32%）超重（BMI ≥ 25和30）。哮喘严重程度指标包括呼吸道症状、医疗保健利用、药物使用、缺勤天数和全球哮喘倡议（GINA）严重程度分类。模型调整为：性别、种族、年龄、教育、收入、就业状况、吸烟状况、哮喘家族史、居住州和居住在大都市统计区。与非超重受试者相比，患有哮喘的肥胖受试者更可能报告持续症状（OR 1.66，95% CI 1.09 - 2.54），错过更多工作日（OR 1.35，95% CI 1.01 - 1.81），使用短效β受体激动剂（OR 1.36，95% CI 1.06 - 1.75），使用吸入性皮质类固醇（OR 1.34，95% CI 1.01 - 1.79）和根据GINA指南使用任何控制性药物（OR 1.37，95% CI 1.01 - 1.85）。此外，肥胖的受访者不太可能在哮喘缓解（OR 0.56，95% CI 0.38 - 0.82），更可能患有重度持续性哮喘（GINA IV）（OR 1.42，95% CI 1.05至1.90）。在一个大的，多样化的成人哮喘样本中，在调整潜在的混杂因素后，肥胖与哮喘严重程度的测量相关。
Background: The association between obesity and asthma severity remains controversial and limited to small studies.Methods: We determined the association of body mass index (BMI) and asthma severity in the National Asthma Survey. We included adults (age >= 18 years) who self-reported symptoms of asthma in the past 5 years. A total of 3095 patients were divided into the following BMI categories: 1080 (35%) non-overweight (BMI,25), 993 (32%) overweight (BMI >= 25 and 30). Asthma severity measures included respiratory symptoms, healthcare utilisation, medication use, missed work days and the Global Initiative for Asthma (GINA) severity classification. Models were adjusted for: gender, race, age, education, income, employment status, smoking status, family history of asthma, state of residence and residence in a metropolitan statistical area.Results: Compared with non-overweight subjects, obese subjects with asthma were more likely to report continuous symptoms (OR 1.66, 95% CI 1.09 to 2.54), miss more work days (OR 1.35, 95% CI 1.01 to 1.81), use short acting beta agonists (OR 1.36, 95% CI 1.06 to 1.75), use inhaled corticosteroids (OR 1.34, 95% CI 1.01 to 1.79) and use any controller medication according to GINA guidelines (OR 1.37, 95% CI 1.01 to 1.85). Also, obese respondents were less likely to be in asthma remission (OR 0.56, 95% CI 0.38 to 0.82) and were more likely to have severe persistent asthma (GINA IV) (OR 1.42, 95% CI 1.05 to 1.90).Conclusions: In a large, diverse sample of adults with asthma, obesity was associated with measures of asthma severity after adjusting for potential confounders.