A mini-review on synthesis and antiviral activity of natural product oxetanocin A derivatives
A mini-review on synthesis and antiviral activity of natural product oxetanocin A derivatives
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天然产物氧他星A衍生物的合成及抗病毒活性简评
DOI：
10.1016/j.bmc.2022.116968
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发表时间：
2022
影响因子：
3.5
通讯作者：
Yang Guang-Fu
中科院分区：
文献类型：
--
作者：
Yan Yao-Chao;Zhang Hu;Hu Kai;Zhou Shao-Meng;Chen Qiong;Qu Ren-Yu;Yang Guang-Fu
Oxetanocin A（Oxt-A）是1986年从巨大芽孢杆菌（Bacillus megaterium）中分离得到的一种新的氧杂环丁烷糖基N-糖苷核苷。它在核苷支架的糖部分上携带氧杂环丁烷环，这有助于其结构与常见的四氢呋喃基核苷的结构不同。鉴于独特的3D空间框架，多个研究小组已经实现了Oxt-A的完全合成。这种天然产物的药理学特性也被药剂师和化学家广泛研究，因为它的发现。值得注意的是，Oxt-A的潜在抗病毒作用引起了抗病毒剂开发领域研究人员的注意。此外，在过去的几十年里，由病毒引起的流行病爆发一直在刺激各种Oxt-A类似物的制备和修饰。然而，没有一项研究概述了这种天然支架的抗病毒功效。本文综述了Oxt-A及其衍生物的合成、结构修饰和抗病毒活性。我们相信，这些全面的描述将为发现具有良好性能的抗病毒药物提供新的视角，并为未来应对病毒引发的突发公共卫生问题铺平新的道路。
Oxetanocin A (Oxt-A), a novel oxetanosylN-glycoside nucleoside, was isolated fromBacillus megateriumin 1986. It carries an oxetane ring on the sugar moiety of the nucleoside scaffold, which contributes to differences in its structure from those of common tetrahydrofuranyl-based nucleosides. In view of the unique 3D-spatial framework, the complete synthesis of Oxt-A has been achieved by multiple research groups. The pharmacological properties of this natural product have also been broadly investigated by pharmacists and chemists since its discovery. Notably, the potential antiviral effect of Oxt-A has captured attention of researchers in the field of antiviral agent development. Furthermore, epidemic outbreaks caused by viruses have been stimulating the preparation and modification of various Oxt-A analogs over the past few decades. However, none of the studies have overviewed the antiviral efficacies of this naturally occurring scaffold yet. Thus, the present review summarizes the synthesis, structural modification, and antiviral activities of Oxt-A and its derivatives. We believe that these comprehensive descriptions will provide a novel perspective for the discovery of antivirus drugs with well-improved performance and pave newer paths for combating sudden public health issues triggered by viruses in the future.