p53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis
p53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis
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p53 密码子 72 多态性与复发性流产：荟萃分析
DOI：
10.1007/s10815-011-9618-5
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发表时间：
2011-09-01
影响因子：
3.1
通讯作者：
Luo, Ying
中科院分区：
文献类型：
--
作者：
Tang, Wenru;Zhou, Xuhong;Luo, Ying
研究背景P53抑癌基因Arg72Pro多态与复发性妊娠丢失相关。然而，结果并不一致。我们进行了这项荟萃分析，以更准确地估计P53密码子72多态与复发性妊娠丢失之间的关联。选择包含Arg72Pro可用基因频率的病例对照研究，用95%可信区间(CI)的优势比(OR)来评估这种关联的强度。Meta分析显示，在合并分析中，携带Pro/Pro纯合子的个体再次妊娠丢失的风险增加(OR=1.85，95%CI：1.078，与3.173相似，P=0.025)。对称漏斗图、Egger‘s检验(P=0.497)和Begg检验(P=0.85)均提示无发表偏倚。结论该Meta分析支持P53/72Pro/Pro基因与再妊娠丢失风险增加相关的观点。为了得出全面和真实的结论，需要在全球范围内对更多的参与者进行进一步的前瞻性研究，以检查P53密码子72多态与反复妊娠丢失之间的关系。
Background Arg72Pro polymorphism of the p53 tumour suppressor gene have been associated with recurrent pregnancy loss. However, results were inconsistent. We performed this metaanalysis to drive amore precise estimation of association between p53 codon 72 polymorphism and recurrent pregnancy loss.Methods Electronic searche of PubMed was conducted to select studies. Case-control studies containing available genotype frequencies of Arg72Pro were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.Results 4 case-control studies including 523 cases and 378controls were identified. This meta-analysis showed that individuals with the homozygous Pro/Pro genotype had increased risk of recurrent pregnancy loss (OR = 1.85, 95% CI: 1.078 similar to 3.173, p = 0.025) in the pooled analyses. An symmetric funnel plot, the Egger's test (P = 0.497), and the Begg- test (P = 0.85) were all suggestive of the lack of publication bias.Conclusion This meta-analysis supports the idea that p53 condon72 Pro/Pro genotype is associated with increased risk of recurrent pregnancy loss. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between p53 codon 72 polymorphism and recurrent pregnancy loss.