High Cholesterol at the Heart of Phagolysosomal Damage.
High Cholesterol at the Heart of Phagolysosomal Damage.
复制标题
高胆固醇是吞噬溶酶体损伤的核心。
DOI：
10.1016/j.cmet.2018.02.015
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发表时间：
2018
期刊：
影响因子：
29
通讯作者：
Swanson,JoelA
中科院分区：
文献类型：
--
作者：
Lieberman,AndrewP;Swanson,JoelA
Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. InScience, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.
