Hypothalamic reward mechanism: two first-stage fiber populations with a cholinergic component.
Hypothalamic reward mechanism: two first-stage fiber populations with a cholinergic component.
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下丘脑奖励机制：两个具有胆碱能成分的第一阶段纤维群。
DOI：
10.1126/science.2981439
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Wise,RA
中科院分区：
文献类型：
--
作者：
Gratton,A;Wise,RA
估计脑刺激奖励的下丘脑基质纤维的不应期。两个不重叠的群体是明显的：同质的快速群体和更加异质的慢速群体。胆碱能阻断消除了快纤维的贡献，但没有消除慢纤维的贡献，而多巴胺能阻断减少了反应，但没有显着影响直接激活的纤维群。这些数据表明，下丘脑奖赏底物比人们普遍认识的更为复杂。它包含两个或多个并行子系统，其中一个子系统具有胆碱能链接。
Refractory periods were estimated for fibers of the hypothalamic substrate of brain stimulation reward. Two nonoverlapping populations were evident: a homogeneous fast population and a more heterogeneous slow population. Cholinergic blockade eliminated the contribution of the fast but not the slow fibers, while dopaminergic blockade reduced responding without significantly influencing either directly activated fiber population. These data indicate that the hypothalamic reward substrate is more complex than has been widely appreciated; it contains two or more parallel subsystems, and one of these subsystems has a cholinergic link.