Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women.
Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women.
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DOI：
10.1017/s0033291723000612
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发表时间：
2023-11
影响因子：
6.9
通讯作者：
Kubzansky, Laura D. D.
中科院分区：
文献类型：
--
作者：
Ke, Shanlin;Guimond, Anne-Josee;Tworoger, Shelley S.;Huang, Tianyi;Chan, Andrew T. T.;Liu, Yang-Yu;Kubzansky, Laura D. D.
越来越多的证据表明，积极和消极的情绪以及情绪调节在人类健康和疾病中起着关键作用。最近的研究表明，肠道微生物组在通过肠道-大脑轴调节心理和身体健康方面非常重要。然而，它与情绪和情绪调节的关系却研究不足。在这里，我们研究了积极和消极情绪以及两种情绪调节策略（即认知重新评价和抑制）是否与健康女性的肠道微生物组组成和功能途径相关。参与者来自身心研究（N = 206，平均年龄= 61），这是护士健康研究II队列的子研究。在2013年，参与者完成了情绪相关因素的测量。两对粪便样本，间隔6个月，3个月后，情绪相关因素的措施完成。分析研究了情绪相关因素与肠道微生物多样性，整体微生物组结构和特定物种/途径的关联，并对相关协变量进行了调整。α多样性与抑制呈负相关。在多变量分析中，积极的情绪与厚壁菌门细菌CAG 94和瘤胃球菌科细菌D16的相对丰度呈负相关，而消极的情绪与这些相同物种的相对丰度直接相关。在代谢途径水平上，负面情绪与泛酸、辅酶A和腺苷的生物合成呈负相关。这些发现提供了支持情绪和相关调节过程与肠道微生物组之间联系的人类证据，并强调了将肠道微生物组纳入我们对情绪相关因素及其与身体健康关系的理解中的重要性。
Accumulating evidence suggests that positive and negative emotions, as well as emotion regulation, play key roles in human health and disease. Recent work has shown the gut microbiome is important in modulating mental and physical health through the gut–brain axis. Yet, its association with emotions and emotion regulation are understudied. Here we examined whether positive and negative emotions, as well as two emotion regulation strategies (i.e. cognitive reappraisal and suppression), were associated with the gut microbiome composition and functional pathways in healthy women. Participants were from the Mind-Body Study (N = 206, mean age = 61), a sub-study of the Nurses' Health Study II cohort. In 2013, participants completed measures of emotion-related factors. Two pairs of stool samples were collected, 6 months apart, 3 months after emotion-related factors measures were completed. Analyses examined associations of emotion-related factors with gut microbial diversity, overall microbiome structure, and specific species/pathways and adjusted for relevant covariates. Alpha diversity was negatively associated with suppression. In multivariate analysis, positive emotions were inversely associated with the relative abundance of Firmicutes bacterium CAG 94 and Ruminococcaceae bacterium D16, while negative emotions were directly correlated with the relative abundance of these same species. At the metabolic pathway level, negative emotions were inversely related to the biosynthesis of pantothenate, coenzyme A, and adenosine. These findings offer human evidence supporting linkages of emotions and related regulatory processes with the gut microbiome and highlight the importance of incorporating the gut microbiome in our understanding of emotion-related factors and their associations with physical health.