Three dimensional structural insight of laser drilled orifices in osmotic pump tablets
Three dimensional structural insight of laser drilled orifices in osmotic pump tablets
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渗透泵片中激光钻孔的三维结构洞察
DOI：
10.1016/j.ejps.2016.08.039
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发表时间：
2016-10-10
影响因子：
4.6
通讯作者：
Zhang, Jiwen
中科院分区：
文献类型：
--
作者：
Wu, Li;Wang, Lebing;Zhang, Jiwen
在渗透泵中，作为药物输送通道的孔是药物控释系统的关键功能部件。报道的这些孔的常规显微镜评价仅限于二维横截面直径的测量。本研究旨在建立一种基于同步辐射X射线微计算机断层扫描（SR-mu CT）的定量测量孔窍三维结构的新方法。定量分析了不同操作参数下开孔的渗透泵结构，结果表明，激光功率与开孔的截面积、体积、表面积和深度相关，而激光扫描速度与开孔的截面积、体积、表面积和深度呈负相关。基于同步辐射的傅里叶变换红外显微光谱图显示，与正常膜区域相比，孔周围区域没有明显的化学变化。因此，SR-mu CT成功应用于市售非洛地平渗透泵，用于孔的结构评价。总之，第一个三维结构的洞察渗透泵片孔SR-mu CT和结构重建的架构提供了更深入的了解，以改善先进的渗透泵的设计控制药物释放。(C)2016由Elsevier B. V.出版
The orifice drilled in the membrane as a channel for drug delivery is the key functional part of the osmotic pumps for a controlled drug release system. Reported conventional microscopic evaluations of these orifices have been limited to measurement of two-dimensional cross-section diameters. This study was aimed at establishing a novel method to measure quantitatively the three-dimensional architectures of orifices based on synchrotron radiation X-ray microcomputed tomography (SR-mu CT). Quantitative analysis of architectures extracted from captopril osmotic pumps drilled by a range of operating parameters indicated that laser power correlated with the cross section area, volume, surface area and depth of the orifices, while scanning speed of laser beam showed inverse relationships with the above structure characters. The synchrotron radiation based Fourier transform infrared microspectroscopy mapping showed that there was no apparent chemical change in the surrounding area of the orifice compared with the normal membrane region. Thus SR-mu CT was successfully applied to marketed felodipine osmotic pumps for architectural evaluation of the orifices. In conclusion, the first three-dimensional structural insight of orifices in osmotic pump tablets by SR-mu CT and structural reconstruction for the architectures has provided deeper insight into improving the design of advanced osmotic pumps for controlled drug release. (C) 2016 Published by Elsevier B.V.