Characteristics of missed prostate cancer lesions on 3T multiparametric-MRI in 518 patients: based on PI-RADSv2 and using whole-mount histopathology reference
Characteristics of missed prostate cancer lesions on 3T multiparametric-MRI in 518 patients: based on PI-RADSv2 and using whole-mount histopathology reference
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DOI：
10.1007/s00261-018-1823-6
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发表时间：
2019-03-01
影响因子：
2.4
通讯作者：
Raman, Steven S.
中科院分区：
文献类型：
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作者：
Bajgiran, Amirhossein Mohammadian;Mirak, Sohrab Afshari;Raman, Steven S.
目的基于PI-RADSv2与全载组织病理学（WMHP）相关，探讨3T多参数mri （mpMRI）漏诊前列腺癌（PCa）病变的特征。材料和方法本研究经irb批准，符合hipaa标准，于2009年12月至2017年4月在单一三级中心连续614名男性接受3T mpMRI前列腺切除术。获得临床、mpMRI和病理特征。一名泌尿生殖系统（GU）放射科医生和一名泌尿生殖系统病理学家将基于pi - radsv2的MRI检测到的病变与先前确定的WMHP相匹配。没有mpMRI检测到PCa病变，但在WMHP上至少有一个1cm的病变的患者，回顾性回顾并分配PI-RADSv2评分。比较未发现和已发现病变的肿瘤特征。结果最终队列包括518例WMHP病变1085例。51.9%（563/1085）的病变在3T mpMRI上未被发现。71.4%（402/563）、21.7%（122/563）、4.4%（25/563）和2.5%（14/563）的漏诊病灶分别为Gleason评分（GS） 3+3、3+4、4+3和8-10。未检出的PCa病变中GS7的比例明显降低(p
PurposeTo determine the characteristics of missed prostate cancer (PCa) lesions on 3T multiparametric-MRI (mpMRI) based on PI-RADSv2 with whole-mount histopathology (WMHP) correlation.Materials and methodsThis IRB-approved, HIPAA-compliant study, included 614 consecutive men with 3T mpMRI prior to prostatectomy at a single tertiary center between 12/2009 and 4/2017. Clinical, mpMRI, and pathologic features were obtained. PI-RADSv2-based MRI detected lesions were matched with previously finalized WMHP by a genitourinary (GU) radiologist and a GU pathologist. Patients with no mpMRI detected PCa lesion, but with at least one lesion1cm on WMHP, were reviewed retrospectively and assigned a PI-RADSv2 score. Tumor characteristics were compared between missed and detected lesions.ResultThe final cohort included 518 patients with 1085 WMHP lesions. 51.9% (563/1085) of lesions were missed on 3T mpMRI. 71.4% (402/563), 21.7% (122/563), 4.4% (25/563), and 2.5% (14/563) of the missed lesions were Gleason scores (GS) 3+3, 3+4, 4+3, and 8-10, respectively. Missed PCa lesions had significantly lower proportion of GS7 (p