Movement-related activity in the periarcuate cortex of monkeys during coordinated eye and hand movements
Movement-related activity in the periarcuate cortex of monkeys during coordinated eye and hand movements
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DOI：
10.1152/jn.00279.2017
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发表时间：
2017-12-01
影响因子：
2.5
通讯作者：
Kurata, Kiyoshi
中科院分区：
文献类型：
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作者：
Kurata, Kiyoshi
为了确定弓状皮质在猴眼和手的协调运动中的作用，本研究检测了在手、眼或两者作为视觉空间目标效应器的运动中该区域的神经元活动。与初级运动皮质(M1)类似，背侧运动前皮质含有更高比例的与手运动密切相关的神经元，而与眼跳相关的神经元通常来自额叶眼场(FEF)。有趣的是，表现出与眼睛和手运动相关的活动的神经元最常被记录在位于FEF和M1之间的腹侧运动前皮质(PMV)。与眼球或手部运动相比，在协调运动过程中，弓状回皮质的神经元活动受到高度调节。此外，在三种任务模式中的一种模式下，少数神经元特别活跃，这可能与效应器的活动相分离。在这种情况下，神经元的开始要么在眼睛和/或手运动的开始之前，要么在开始之后，一些神经元的活动一直持续到奖赏传递信号成功完成到达。本研究结果表明，弓状回皮质，尤其是PMV，在协调从开始到终止触觉的协调运动中起着重要作用。在猴子的弓状回皮质中，记录到了与运动相关的新的和值得注意的神经元活动，这些猴子完成了一项任务，要求他们只移动他们的手，只移动他们的眼睛，或者将手和眼睛都移动到视觉空间目标上。最典型的是，无论不同的效应器，从运动开始到成功结果的完成，神经元通常都是活跃的。这一发现表明，弓状皮质作为一个整体，在启动和完成眼-手协调运动方面起着至关重要的作用。
To determine the role of the periarcuate cortex during coordinated eye and hand movements in monkeys, the present study examined neuronal activity in this region during movement with the hand, eyes, or both as effectors toward a visuospatial target. Similar to the primary motor cortex (M1), the dorsal premotor cortex contained a higher proportion of neurons that were closely related to hand movements, whereas saccade-related neurons were frequently recorded from the frontal eye field (FEF). Interestingly, neurons that exhibited activity related to both eye and hand movements were recorded most frequently in the ventral premotor cortex (PMv), located between the FEF and M1. Neuronal activity in the periarcuate cortex was highly modulated during coordinated movements compared with either eye or hand movement only. Additionally, a small number of neurons were active specifically during one of the three task modes, which could be dissociated from the effector activity. In this case, neuron onset was either ahead of or behind the onset of eye and/or hand movement, and some neuronal activity lasted until reward delivery signaled successful completion of reaching. The present findings indicate that the periarcuate cortex, particularly the PMv, plays important roles in orchestrating coordinated movements from the initiation to the termination of reaching.NEW & NOTEWORTHY Movement-related neuronal activity was recorded throughout the periarcuate cortex of monkeys that performed a task requiring them to move their hand only, eyes only, or both hand and eyes toward visuospatial targets. Most typically, neurons were found that were commonly active regardless of different effectors, from movement initiation to completion of a successful outcome. The findings suggest that the periarcuate cortex as a whole plays a crucial role in initiating and completing coordinated eye-hand movements.