Prospective randomized evaluation of prophylactic antibiotic usage in patients undergoing tension free inguinal hernioplasty
Prospective randomized evaluation of prophylactic antibiotic usage in patients undergoing tension free inguinal hernioplasty
复制标题
无张力腹股沟疝修补术患者预防性抗生素使用的前瞻性随机评估
DOI：
10.1007/s10029-011-0783-3
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发表时间：
2011
期刊：
影响因子：
2.3
通讯作者：
I. Othman
中科院分区：
文献类型：
--
作者：
I. Othman
ObjectivesAssessment of the useful of antibiotics prevention in腹股沟疝plasty.Materials and MethodsThis前瞻性随机双盲研究进行了98例患者。A组（50例）在麻醉诱导前30 min单次静脉注射阿莫西林和克拉维酸，P组（48例）在麻醉诱导前30 min静脉注射等体积生理盐水安慰剂。使用聚丙烯补片进行疝修补术。使用皮肤斯台普斯闭合皮肤，在伤口完全愈合后取出。www.apic.org结果A组平均手术时间（38.8 ± 10.8）min，P组平均手术时间（40.9 ± 11.1）min（P = 0.34）。A组平均住院时间为1.3 ± 0.463天，P组为1.25 ± 0.438天（P = 0.58）。A组4例患者（2%）和P组6例患者（2.88%）发生伤口感染（P = 0.47）。A组浅表感染3例，深部感染1例; P组浅表感染5例，深部感染1例。所有患者的伤口感染抗生素治疗均获得成功。伤口培养显示每组各1例患者发生金黄色葡萄球菌感染，A组1例患者发生化脓性链球菌感染，P组1例患者发生铜绿假单胞菌感染。在其他患者在这两个groups. ConclusionPreventive抗生素的使用进行无张力腹股沟疝修补术的患者在减少手术部位感染没有表现出任何统计学上显着的有益效果。
ObjectivesAssessment of the usefulness of antibiotic prophylaxis in inguinal hernioplasty.Materials and methodsThis prospective randomized double blind study was conducted on 98 patients. Group A (50 patients) received a single dose of intravenous amoxicillin and clavulanic acid, and Group P (48 patients) received an equal volume of normal saline placebo by intravenous bolus 30 min before the induction of anesthesia. Hernioplasty was performed with polypropylene mesh. Skin was closed using skin staples that were removed after complete wound healing. The surgical site infection was diagnosed according to APIC, CDC criteria (http://www.apic.org).ResultsThe mean operative time was 38.8 ± 10.8 min in group A versus 40.9 ± 11.1 min in group P (P = 0.34). The mean hospitalization time was 1.3 ± 0.463 days in group A versus 1.25 ± 0.438 days in group P (P = 0.58). Four patients (2%) in group A and 6 patients (2.88%) in group P had wound infections (P = 0.47). Group A had 3 superficial infections and 1 deep infection while group P had 5 superficial infections and 1 deep infection. Antibiotic treatment of the wound infection was successful in all patients. Wound culture showed Staphylococcus aureus infection in 1 patient each group, Streptococcus pyogenes in 1 group A patient and Pseudomonas aeruginosa in 1 group P patient. Cultures in other patients in both groups were reported to be sterile.ConclusionProphylactic antibiotic usage in patients undergoing tension free inguinal hernioplasty did not show any statistically significant beneficial effects in reduction of surgical site infection.