A collaborative study of cytomegalovirus antibodies in mothers and young children in 19 countries.
A collaborative study of cytomegalovirus antibodies in mothers and young children in 19 countries.
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对 19 个国家的母亲和幼儿进行的巨细胞病毒抗体合作研究。
DOI：
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发表时间：
1981
影响因子：
11.1
通讯作者：
J. Tobin
中科院分区：
文献类型：
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作者：
U. Krech;J. Tobin
通过检测世界19个不同地区婴儿和4岁以下儿童的脐带血和血清样本中巨细胞病毒（CMV）抗体的存在，研究了母亲和幼儿注射CMV的发生率的地区差异。由当地病毒实验室和参考实验室使用相同批次的补体固定CMV抗原和技术对样本进行检测，并通过比较发送至每个实验室的编码血清样本的滴度进行验证。CMV抗体的发生率在母亲中为44-100%，在幼儿中为3-95%。在五个地区，携带CMV抗体的儿童人数随着年龄的增长而增加;这表明这些地区的儿童之间存在CMV感染的儿童传播。在其他区域，没有出现任何与年龄相关的显著增加，表明生命早期CMV感染的主要途径是母亲向婴儿传播。这些发现的意义进行了讨论。
Regional variations in the incidence of cytomegalovirus (CMV) injections in mothers and young children were investigated by testing cord blood and serum samples from infants and children up to four years old for the presence of CMV antibodies in 19 different regions of the world. The samples were tested by both the local virus laboratory and the reference laboratory, using the same batch of complement-fixing CMV antigen and techniques which were validated by comparison of the titres recorded for samples of coded sera sent to each laboratory. The incidence of CMV antibodies varied from 44-100% in mothers and from 3-95% in young children. The number of children with CMV antibodies increased with age in five areas; suggesting that there was some child to child transmission of CMV infection between children in these regions. In the other regions, the absence of any significant age-related increase indicated that the main pathway of CMV infection in early life was by transmission from mothers to their infants. The significance of these findings is discussed.