Membrane voltage as a dynamic platform for spatiotemporal signaling, physiological, and developmental regulation.
Membrane voltage as a dynamic platform for spatiotemporal signaling, physiological, and developmental regulation.
复制标题
膜电压作为时空信号、生理和发育调节的动态平台。
DOI：
10.1093/plphys/kiab032
复制
发表时间：
2021-04-23
期刊：
影响因子：
7.4
通讯作者：
Alvim JC
中科院分区：
文献类型：
--
作者：
Klejchova M;Silva-Alvim FAL;Blatt MR;Alvim JC
膜电压产生于离子通过离子转运ATP酶、溶质的离子偶联转运和离子通道的转运，并且是膜的生物能“流通”的组成部分。膜电压的动力学--所谓的动作电位、系统电位和变异电位--也使人们认识到它们在细胞内和组织间信号转导中的作用。在这里，我们回顾了我们对膜电压的理解的起源，以及它作为调节运输和信号传递的中心元素的位置。我们强调的重要性，了解电压作为一个共同的中间体，既作为运输的驱动力-一个电“基板”-和跨膜的电荷通量的产品，从而互连所有的跨膜电荷携带运输。电压互连对于经由依赖于离子通量的第二信使的信号传导是至关重要的，所述离子通量包括胞质游离Ca 2+、H+以及由完整膜、呼吸爆发氧化酶产生的活性氧物质的合成。这些特征告知长距离电压信号和电压振荡引起独特的基因表达模式和影响生理，发育和适应性反应，如系统获得性抗性病原体和昆虫植食性的方式。膜电压作为一个平台，协调离子通量，以传递和传递生物信号。
Membrane voltage arises from the transport of ions through ion-translocating ATPases, ion-coupled transport of solutes, and ion channels, and is an integral part of the bioenergetic “currency” of the membrane. The dynamics of membrane voltage—so-called action, systemic, and variation potentials—have also led to a recognition of their contributions to signal transduction, both within cells and across tissues. Here, we review the origins of our understanding of membrane voltage and its place as a central element in regulating transport and signal transmission. We stress the importance of understanding voltage as a common intermediate that acts both as a driving force for transport—an electrical “substrate”—and as a product of charge flux across the membrane, thereby interconnecting all charge-carrying transport across the membrane. The voltage interconnection is vital to signaling via second messengers that rely on ion flux, including cytosolic free Ca2+, H+, and the synthesis of reactive oxygen species generated by integral membrane, respiratory burst oxidases. These characteristics inform on the ways in which long-distance voltage signals and voltage oscillations give rise to unique gene expression patterns and influence physiological, developmental, and adaptive responses such as systemic acquired resistance to pathogens and to insect herbivory. Membrane voltage serves as a platform coordinating ion flux to transmit and transduce biological signals.
登录
查看更多内容
DOI：
10.1085/jgp.99.4.615
发表时间：
1992-04
期刊：
The Journal of general physiology
影响因子：
--
作者：
Blatt MR
通讯作者：
Blatt MR
DOI：
10.1073/pnas.84.9.2737
发表时间：
1987-05-01
影响因子：
11.1
作者：
BLATT, MR;SLAYMAN, CL
通讯作者：
SLAYMAN, CL
影响因子：
7.2
作者：
Bright, J;Desikan, R;Neill, SJ
通讯作者：
Neill, SJ
DOI：
10.1007/bf01790181
发表时间：
1902-11-01
影响因子：
--
作者：
Bernstein, J
通讯作者：
Bernstein, J
影响因子：
7.2
作者：
BLATT, MR;THIEL, G
通讯作者：
THIEL, G