Measurement of regional cerebral blood volume by emission tomography
Measurement of regional cerebral blood volume by emission tomography
复制标题
发射断层扫描测量局部脑血容量
作者：
R. Grubb;M. Raichle;C. S. Higgins;J. Eichling
使用正电子发射断层扫描技术测量10名正常右利手志愿者吸入微量回旋加速器产生的11 C标记一氧化碳后的脑血容量（CBV）。在眶耳道线上方4 cm处获得的扫描中，CBV为4.3 ml/100 gm组织，而在眶耳道线上方8 cm处获得的扫描中，CBV显著更低（3.3 ml/100 gm; p < 0.001）。这种差异反映了在较低的扫描中灰质的比例更大。此外，在眶耳道线上方4cm处获得的断层扫描中，左侧大脑半球的CBV显著更大（p < 0.001）。这些扫描包括颞叶的上级表面区域（颞平面），在左脑语言优势的个体中，该区域被认为更大。这一观察结果是人类大脑半球中已知功能差异的结构相关性的首次体内证明。
The technique of positron emission tomography was used to measure cerebral blood volume (CBV) in 10 normal right‐handed human volunteers following inhalation of trace quantities of cyclotron‐produced, 11C‐labeled carbon monoxide. In scans obtained 4 cm above the orbitomeatal line, CBV was 4.3 ml per 100 gm of tissue, whereas in scans obtained 8 cm above the orbitomeatal line, CBV was significantly less (3.3 ml per 100 gm; p < 0.001). This difference reflects the greater proportion of gray matter in the lower scan. Furthermore, the CBV was significantly larger (p < 0.001) in the left cerebral hemisphere in the tomographic scans obtained 4 cm above the orbitomeatal line. These scans include the region of the superior surface of the temporal lobe (planum temporale), which is thought to be larger in individuals with left cerebral dominance for speech. This observation is the first in vivo demonstration of a structural correlate of a known functional difference in the cerebral hemispheres of man.