Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats.
Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats.
复制标题
LH-RH 抗血清可阻断雌性大鼠中氟哌啶醇诱导的高催乳素血症。
作者：
L. Debeljuk;I. Torres;A. Schally
我们研究了注射抗促黄体生成素释放激素血清阻断内源性促黄体生成素释放激素对氟哌啶醇治疗5天后血清催乳素水平升高的影响。急性静脉注射兔抗黄体生成素释放激素血清可显著降低血清黄体生成素水平，阻断氟哌啶醇所致的高催乳素血症。在另一组大鼠中，绵羊抗黄体生成素-RH血清显著降低了血清黄体生成素水平，也降低了先前被氟哌啶醇升高的血清催乳素水平。在去卵巢大鼠，绵羊抗促黄体生成素血清显著降低血清黄体生成素水平，并降低氟哌啶醇预处理后升高的血清催乳素水平。结论：阻断内源性促黄体生成素-RH的作用导致催乳素的释放减少，以响应类似氟哌啶醇的刺激。这些结果支持垂体促性腺激素细胞和促乳素细胞之间可能存在旁分泌相互作用。
We investigated the effect of blocking endogenous LH-RH, by injection of anti-LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action results in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.