Chiral separation of amino acids and glycyl dipeptides by chiral ligand-exchange capillary electrophoresis comparing Cu(II), Co(II), Ni(II) and Zn(II) complexes of three different sugar acids.
Chiral separation of amino acids and glycyl dipeptides by chiral ligand-exchange capillary electrophoresis comparing Cu(II), Co(II), Ni(II) and Zn(II) complexes of three different sugar acids.
复制标题
DOI：
10.1016/j.chroma.2008.05.071
复制
发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
H. Hödl;M. Schmid;G. Gübitz
中科院分区：
文献类型：
--
作者：
H. Hödl;M. Schmid;G. Gübitz
本文研究了铜（Ⅱ）、钴（Ⅱ）、镍（Ⅱ）和锌（Ⅱ）与D-葡萄糖酸、D-糖二酸和L-苏糖酸的配合物作为手性选择剂，在配体交换毛细管电泳中对芳香族氨基酸和甘氨酰二肽的手性拆分。虽然铜（II）是最常用的配体交换毛细管电泳中的中心离子，在d-葡萄糖酸钴（II）的情况下，被证明是一种替代的氨基酸的对映体分离。甘氨酰二肽，但是，解决只有铜（II）配合物。Zn（II）作为中心离子在所有情况下都不是有效的，并且Ni（II）仅实现了一些部分分离。
This paper deals with comparative studies on the use of copper(II), cobalt(II), nickel(II) and zinc(II) complexes of d-gluconic acid, d-saccharic acid and l-threonic acid as chiral selectors for the enantioseparation of aromatic amino acids and glycyl dipeptides using the principle of ligand-exchange capillary electrophoresis. Although copper(II) is the most frequently used central ion in ligand-exchange capillary electrophoresis, in the case of d-gluconic acid cobalt(II) was shown to be an alternative for the enantioseparation of amino acids. Glycyl dipeptides, however, were resolved only with copper(II) complexes. Zn(II) as a central ion was not effective in all cases and with Ni(II) only some partial separations were achieved.