Low ethanol concentrations selectively augment the tonic inhibition mediated by δ subunit-containing GABAA receptors in hippocampal neurons
Low ethanol concentrations selectively augment the tonic inhibition mediated by δ subunit-containing GABAA receptors in hippocampal neurons
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DOI：
10.1523/jneurosci.2040-04.2004
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发表时间：
2004-09-22
影响因子：
5.3
通讯作者：
Mody, I
中科院分区：
文献类型：
--
作者：
Wei, WZ;Faria, LC;Mody, I
在中枢神经元中，紧张性传导被周围水平的抑制性递质GABA激活。在这里，我们表明，在齿状回颗粒细胞，紧张性抑制是由δ亚基含有GABA（A）受体介导的，这种电导增加了低浓度（30 mM）的乙醇。相反，由CA1锥体细胞的含有α 5亚基的受体介导的紧张性抑制不受影响。乙醇对强直性抑制的影响特别降低了齿状回的兴奋性，并将δ亚基依赖性强直性抑制确定为大脑中乙醇作用的可能位点。
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of CA1 pyramidal cells is not affected. The effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the delta subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.