Gene Expression Profiles of the Cochlea and Vestibular Endorgans: Localization and Function of Genes Causing Deafness
Gene Expression Profiles of the Cochlea and Vestibular Endorgans: Localization and Function of Genes Causing Deafness
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DOI：
10.1177/0003489415575549
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发表时间：
2015-05-01
影响因子：
1.4
通讯作者：
Usami, Shin-ichi
中科院分区：
文献类型：
--
作者：
Nishio, Shin-ya;Hattori, Mitsuru;Usami, Shin-ichi
目的：我们试图阐明遗传性听力损失致病基因的基因表达谱以及编码蛋白的定位。方法：相关文献（截至2014年9月）在PubMed数据库中进行检索，并使用定位、表达和分布作为关键词，在遗传性听力损失主页上定位报告与耳聋相关的基因的基因符号。我们的文献回顾，使我们能够系统化的基因表达谱遗传性耳聋的内耳，澄清独特的功能和特定的表达模式，这些基因在耳蜗和前庭endorgans.Conclusions：各种编码分子的协调行动是必不可少的听觉和前庭功能的正常发展和维护。
Objectives: We sought to elucidate the gene expression profiles of the causative genes as well as the localization of the encoded proteins involved in hereditary hearing loss.Methods: Relevant articles (as of September 2014) were searched in PubMed databases, and the gene symbols of the genes reported to be associated with deafness were located on the Hereditary Hearing Loss Honnepage using localization, expression, and distribution as keywords.Results: Our review of the literature allowed us to systematize the gene expression profiles for genetic deafness in the inner ear, clarifying the unique functions and specific expression patterns of these genes in the cochlea and vestibular endorgans.Conclusions: The coordinated actions of various encoded molecules are essential for the normal development and maintenance of auditory and vestibular function.