Microvessel quantification as a measure of angiogenic activity in benign breast tissues lesions - a marker for precancerous disease.
Microvessel quantification as a measure of angiogenic activity in benign breast tissues lesions - a marker for precancerous disease.
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微血管定量作为良性乳腺组织病变中血管生成活性的测量——癌前疾病的标志。
DOI：
10.3892/ijo.4.6.1199
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发表时间：
1994
影响因子：
5.2
通讯作者：
KJ Pienta
中科院分区：
文献类型：
--
作者：
TA Fregene;CM Kellogg;KJ Pienta
新生血管形成是正常乳腺组织转化为癌性表型的关键步骤。我们研究了58例经组织学证实的良性乳腺病变的血管生成活性，通过内皮细胞的VIII因子突出来定量血管生成活性。在400倍放大率下，所有患者的平均微血管计数（MVC）为51/0.19 mm 2，血管生成活性最高的区域（范围为21-113/0.19 mm）。良性组织中的MVC与先前在癌组织中发现的MVC相似。这些数据表明，“血管生成开关”发生在乳腺转化的早期，并且可能存在一个作用，用于使用MVC来识别随后发生乳腺癌的高风险人群。
Neovascularization is a key step in the transformation of normal breast tissue into a cancerous phenotype. We investigated the angiogenic activity of 58 cases of histologically confirmed benign breast lesions quantitating angiogenic activity by factor VIII highlighting of endothelial cells. The mean microvessel count (MVC) for all patients was 51 per 0.19 mm2 in the area of highest angiogenic activity at 400X magnification (range 21-113 per 0.19 mm). MVC in benign tissues were similar to those found previously in cancer tissues. These data suggest that the 'angiogenic switch' occurs early in breast transformation and that a role may exist for the use of MVC in the identification of persons at heightened risk for subsequent development of breast cancer.