Association of Maternal Genital Herpetic Infection with Spontaneous Abortion
Association of Maternal Genital Herpetic Infection with Spontaneous Abortion
复制标题
母亲生殖器疱疹感染与自然流产的关系
作者：
W. E. Josey;J. Wheeler
对 228 名细胞学检测出生殖器疱疹感染妇女的 644 次妊娠、100 名疱疹涂片阴性妇女的 224 次妊娠以及综合医院人群的 2791 次妊娠的结果进行了审查。发现生殖器疱疹感染后怀孕的妇女的流产率（33.3%）显着高于感染前怀孕的妇女（10.8%）或对照组（9.4%和11.5%）。在怀孕前 4 个月内检测出患有生殖器疱疹的 21 名妇女中，有 7 名因流产而终止妊娠。这些观察结果表明生殖器疱疹感染与流产之间存在关联，并指出需要进行协调一致的病毒学、临床和病理学研究，以提供这种关联的进一步证据并了解所涉及的可能机制。
A review was made of the outcome of 644 pregnancies in 228 women with cytologically detected genital herpetic infection, 224 pregnancies in 100 women with negative herpes smears, and 2791 pregnancies in the general hospital population. A significantly higher abortion rate (33.3%) resulted from pregnancies occurring in women after detection of their genital herpetic infection than from pregnancies occurring before the infection was detected (10.8%) or from those in the control group (9.4% and 11.5%). In 21 women with genital herpes detected during the first 4 months of gestation, seven pregnancies terminated in abortion. These observations suggest an association of genital herpetic infection with abortion and point to the need for concerted virologic, clinical, and pathologic studies to provide further evidence of this association and an understanding of the possible mechanisms involved.