Visualization and temporal/spatial characterization of cardiac radiofrequency ablation lesions using magnetic resonance imaging
Visualization and temporal/spatial characterization of cardiac radiofrequency ablation lesions using magnetic resonance imaging
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DOI：
10.1161/01.cir.102.6.698
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发表时间：
2000-08-08
期刊：
影响因子：
37.8
通讯作者：
Halperin, HR
中科院分区：
文献类型：
--
作者：
Lardo, AC;McVeigh, ER;Halperin, HR
背景：本研究的目的是描述一种在磁共振成像（MRI）过程中创建、可视化和监测心脏射频消融（RFA）治疗的系统和方法。方法与结果：采用自制的7F非磁消融导管（4mm电极），在新型实时交互式心脏MRI系统中对6只健康杂种犬右心尖部进行射频消融。使用MRI透视序列将导管定位到心内目标，并使用t2加权快速自旋回波和对比增强t1加权梯度回波序列对消融组织进行成像。通过MRI确定病变大小，并与大体和组织病理学检查的测量结果进行比较。消融的心肌区域表现为与导管尖端直接相邻的高信号区，在射频输送2分钟后可以检测到。病灶在消融后约5分钟达到最大尺寸，而病灶信号强度随时间线性增加，但在12.2+/-2.1分钟时达到平台期。MR显示的病变大小与实际死后病变大小和组织学坏死面积相关性良好（55.4+/-7.2 vs 49.7+/-5.9 mm）， r=0.958， P
Background-The purpose of this study was to describe a system and method for creating, visualizing, and monitoring cardiac radiofrequency ablation (RFA) therapy during magnetic resonance imaging (MRI).Methods and Results-RFA was performed in the right ventricular apex of 6 healthy mongrel dogs with a custom 7F nonmagnetic ablation catheter (4-mm electrode) in a newly developed real-time interactive cardiac MRI system. Catheters were positioned to intracardiac targets by use of an MRI fluoroscopy sequence, and ablated tissue was imaged with T2-weighted fast spin-echo and contrast-enhanced T1-weighted gradient-echo sequences. Lesion size by MRI was determined and compared with measurements at gross and histopathological examination. Ablated areas of myocardium appeared as hyperintense regions directly adjacent to the catheter tip and could be detected 2 minutes after RF delivery. Lesions reached maximum size approximate to 5 minutes after ablation, whereas lesion signal intensity increased linearly with time but then reached a plateau at 12.2+/-2.1 minutes. Lesion size by MR correlated well with actual postmortem lesion size and histological necrosis area (55.4+/-7.2 versus 49.7+/-5.9 mm(2), r=0.958, P