Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital
Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital
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DOI：
10.5588/ijtld.17.0433
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发表时间：
2018-06-01
影响因子：
4
通讯作者：
Hasegawa, N.
中科院分区：
文献类型：
--
作者：
Asakura, T.;Ishii, M.;Hasegawa, N.
背景：对老年肺炎分支杆菌复合体(PMAC)患者的临床特征和健康相关生活质量(HQOL)知之甚少。目的：使用36项简明健康调查问卷和圣乔治呼吸问卷(SGRQ)评估老年PMAC疾病患者的HQOL，并探讨老年PMAC疾病患者HQOL变化的预测因素。方法：本前瞻性队列登记于2012年5月至2015年7月在日本东京庆应义乌大学医院完成，纳入84例老年PMAC病患者；结果：在横断面分析中，老年PMAC病患者的生理、一般健康、活力、社会功能、角色情感和角色/社会因素得分均显著低于日本一般老年人群。协方差分析显示，有空洞性病变的患者的身体功能和SGRQ评分明显较差(P<；0.05)。纵向分析显示，治疗不足、病程短、基线时痰涂片阳性是影响老年PMAC病患者12个月生活质量的危险因素。需要对HQOL进行进一步的大规模研究，以完善这一参数在这些患者的治疗中的使用。
BACKGROUND: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease.OBJECTIVES: To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease.METHODS: This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged >= 75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively.RESULTS: In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months.CONCLUSIONS: Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.