Mechanism of parturition and preterm tabor
Mechanism of parturition and preterm tabor
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DOI：
10.1097/00006254-200010000-00025
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发表时间：
2000-10-01
影响因子：
6.2
通讯作者：
Challis, JRG
中科院分区：
文献类型：
--
作者：
Challis, JRG
早产发生在所有妊娠的5%至10%中，占新生儿死亡率和发病率的75%，包括长期残疾，30%的早产可能与潜在的感染过程有关，大约50%是特发性的，早产对应于具有多种原因的综合征，导致早产的因素在妊娠的不同“窗口期”可能有所不同。糖皮质激素似乎在足月和早产的出生过程中起着核心作用，并改变前列腺素合成和代谢中关键酶的合成和/或活性，以及增加子宫内组织促肾上腺皮质激素释放激素的输出，这一新信息应有助于为有早产风险的患者开发更好的诊断和治疗方法，目标受众：妇科医生和家庭医生学习目标：完成本文后，读者将能够描述潜在的机制，分区和早产，并列出各种物质，可以抑制和促进子宫肌层收缩。
Preterm birth occurs in 5 to 10 percent of all pregnancies and accounts for 75 percent of neonatal mortality and morbidity, including long-term handicap, Thirty percent of preterm birth may be associated with an underlying infective process, and approximately 50 percent are idiopathic, Preterm birth corresponds to a syndrome with a variety of causes, The factors contributing to preterm birth may vary at different "windows" of gestation. Glucocorticoids seem to have a central role in processes of birth at term and preterm, and alter synthesis and/or activity of key enzymes in prostaglandin synthesis and metabolism as well as increasing corticotropin-releasing hormone output by intrauterine tissues, This new information should facilitate development of improved methods of diagnosis and therapy for patients at risk of preterm labor,Target audience: Gynecologists and Family PhysiciansLearning objectives: After completion of this article, the reader will be able to describe potential mechanisms of partition and preterm labor and to list the various substances that can inhibit and promote myometrial contractions.