Recombination of Feline calicivirus within an endemically infected cat colony
Recombination of Feline calicivirus within an endemically infected cat colony
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DOI：
10.1099/vir.0.81537-0
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发表时间：
2006-04-01
影响因子：
3.8
通讯作者：
Radford, AD
中科院分区：
文献类型：
--
作者：
Coyne, KP;Reed, FC;Radford, AD
为了了解杯状病毒科的进化，研究了猫杯状病毒（FCV）在地方性感染的猫群中的持续性。聚合酶和衣壳序列进行了分析的34个FCV分离株超过4年的时间。最初，殖民地被一种病毒株感染，但后来又鉴定出了第二种不同的病毒株。随后，观察到重组病毒的出现，其含有在殖民地内循环的两种菌株的元素。重组事件映射到ORF 1/ORF 2交界处附近。这与其他杯状病毒中的重组一致，表明该家族中存在共同的机制。这是杯状病毒科中的Vesivirus属内重组的首次报道，也是第一次观察到重组事件，其中还鉴定了亲本菌株。
To understand the evolution of the family Caliciviridae, the persistence of Feline calicivirus (FCV) was studied within an endemically infected cat colony. Polymerase and capsid sequences were analysed for 34 FCV isolates obtained over a 4 year period. Initially, the colony was infected with one strain of virus, but a second distinct strain was later identified. Subsequently, the emergence of a recombinant virus was observed, containing elements of both of the strains circulating within the colony. The recombination event mapped close to the ORF1/ORF2 junction. This is consistent with recombination in other caliciviruses, suggesting a common mechanism within this family. This is the first report of recombination within the genus Vesivirus in the family Caliciviridae and the first time that a recombination event has been observed where the parental strains have also been identified.