INDUCTION OF INFLAMMATORY ARTHROPATHY RESEMBLING RHEUMATOID-ARTHRITIS IN MICE TRANSGENIC FOR HTLV-I
INDUCTION OF INFLAMMATORY ARTHROPATHY RESEMBLING RHEUMATOID-ARTHRITIS IN MICE TRANSGENIC FOR HTLV-I
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DOI：
10.1126/science.1887217
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发表时间：
1991-08-30
期刊：
影响因子：
56.9
通讯作者：
SEKIGUCHI, T
中科院分区：
文献类型：
--
作者：
IWAKURA, Y;TOSU, M;SEKIGUCHI, T
人类T细胞白血病病毒I型(HTLV-I)是成人T细胞白血病的病原体，也被认为与其他疾病有关，如慢性关节炎或脊髓病。为了阐明病毒在疾病中的病理作用，生产了携带HTLV-I基因组的转基因小鼠。在2到3个月大的时候，许多小鼠患上了类似类风湿性关节炎的慢性关节炎。滑膜和关节周围炎症明显，肉芽组织侵袭导致关节侵蚀。这些观察表明HTLV-I可能是人类慢性关节炎的病原体之一。
Human T cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T cell leukemia and has also been suggested to be involved in other diseases such as chronic arthritis or myelopathy. To elucidate pathological roles of the virus in disease, transgenic mice were produced that carry the HTLV-I genome. At 2 to 3 months of age, many of the mice developed chronic arthritis resembling rheumatoid arthritis. Synovial and periarticular inflammation with articular erosion caused by invasion of granulation tissues were marked. These observations suggest a possibility that HTLV-I is one of the etiologic agents of chronic arthritis in humans.