Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
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DOI：
10.1001/archneur.63.1.97
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Thompson, PM
中科院分区：
文献类型：
--
作者：
Becker, JT;Davis, SW;Thompson, PM
目的：使用三维网格重建测量诊断为轻度认知障碍（MCI）亚型的患者相对于老年对照受试者和阿尔茨海默病（AD）患者的海马体积。设计：MCI亚组的磁共振成像体积研究（MCI，遗忘亚型[MCI-A];和MCI，多认知域亚型）。26例MCI受试者（MCI-A，n = 6; MCI，多认知域亚型，n= 20），20名AD受试者，和20名年龄、教育和性别分布相当的对照者。主要结果测量：海马和总海马体积的三维参数网格模型。与健康对照组相比，AD患者的小脑萎缩明显。多认知域亚型MCI组与对照组无差异，但与MCI-A组和AD组有显著差异。与对照组相比，MCI-A患者有显着的海马萎缩，并没有显着差异AD患者。结论：这些数据增加了越来越多的证据表明，有多种形式的MCI，他们有不同的神经病理相关性，MCI，多个认知域亚型，是不是一个更先进的形式的MCI-A亚型。
Objective: To measure hippocampal volumes in patients diagnosed as having subtypes of mild cognitive impairment (MCI) relative to those of elderly control subjects and those of patients with Alzheimer disease (AD) using 3-dimensional mesh reconstructions.Design: A magnetic resonance imaging volumetric study of MCI subgroups (MCI, amnesic subtype [MCI-A]; and MCI, multiple cognitive domain subtype) using 3-dimensional mesh reconstructions of the structure.Setting: Referral dementia clinic.Subjects: Twenty-six subjects with MCI (MCI-A, n = 6; and MCI, multiple cognitive domain subtype, n= 20), 20 subjects with AD, and 20 controls who were equivalent in age, education, and sex distributions.Main Outcome Measures: Three-dimensional parametric mesh models of the hippocampus and total hippocampal volumes.Results: The hippocampi of the patients with AD were significantly atrophic relative to those of the healthy controls. The MCI, multiple cognitive domain subtype, group did not differ from the controls, yet was significantly different from the MCI-A and the AD groups. The MCI-A patients had significant hippocampal atrophy compared with the controls, and did not differ significantly from the patients with AD.Conclusion: These data add to the growing evidence that there are multiple forms of MCI, that they have distinct neuropathological correlates, and that MCI, multiple cognitive domain subtype, is not a more advanced form of the MCI-A subtype.