Anxiolytic effects of progesterone are sexually dimorphic.
Anxiolytic effects of progesterone are sexually dimorphic.
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黄体酮的抗焦虑作用具有性别二态性。
DOI：
10.1016/0024-3205(86)90139-6
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Hendricks,SE
中科院分区：
文献类型：
--
作者：
Rodriguez-Sierra,JF;Hagley,MT;Hendricks,SE
我们评估了在舔抑制试验中给予雌激素致敏大鼠孕酮对舔行为的影响。该测试评估了缺水大鼠舔饮水管以获得与电击配对的水强化的行为。在这个测试中，氯氮卓（一种常用的镇静剂）在增加舔舔方面非常有效。在注射激素后进行的测试中，正常女性和经阉割的男性显示出电击惩罚反应的增加。正常雄性和卵巢雄激素化雌性不受影响。我们的研究结果表明，卵巢类固醇，特别是孕酮，可以调节女性和女性化男性的焦虑。此外，黄体酮的抗焦虑作用似乎是由一种不同于利血平的机制介导的。
We evaluated the effects of progesterone administration to estrogen-primed rats on licking behavior during a lick suppression test. This test assesses the behavior of water-deprived rats to lick a drinking tube for water reinforcement that is paired to electric shock. Chlordiazepoxide (a commonly used tranquilizer) is very effective in increasing licking during this test. Normal females and neonatally castrated males displayed an increase in shock-punished responses in tests conducted after hormone injections. Normal males and neonatally androgenized females were unaffected. Our results suggest that ovarian steroids, and particularly progesterone, can modulate anxiety in females and feminized males. In addition, the anxiolytic effect of progesterone appears to be mediated by a mechanism different from that of Chlordiazepoxide.