Stochastic facilitation of artificial tactile sensation in primates.
Stochastic facilitation of artificial tactile sensation in primates.
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DOI：
10.1523/jneurosci.3115-12.2012
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发表时间：
2012-10-10
期刊：
影响因子：
--
通讯作者：
Nicolelis MA
中科院分区：
文献类型：
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作者：
Medina LE;Lebedev MA;O'Doherty JE;Nicolelis MA
通过电或光刺激大脑感觉区域的人工感觉为感觉缺陷提供了有希望的治疗。对于脑-机-脑接口（BMBI），这种人工感觉从传感器化假肢传递反馈信号。然而，神经组织可以被刺激以唤起人工感觉的方式以及这种刺激的参数空间在很大程度上仍未被探索。在这里，我们调查是否随机易化（SF）可以增强皮质内微刺激（ICMS）产生的人工触觉。两只恒河猴学会了使用一只虚拟的手，它们用操纵杆移动，来探索电脑屏幕上的虚拟物体。他们寻找一个与特定人造纹理（AT）相关的物体，该纹理由一对植入电极传递到初级躯体感觉皮层（S1）的周期性ICMS模式发出信号。在每次行为试验期间，非周期性ICMS（即，噪声）通过另一个植入距离AT输送部位1 mm处的电极对输送到S1。高振幅噪声使AT检测恶化，而中等噪声明显改善了弱信号的检测，显著提高了正确试验的比例。这些发现表明，SF可用于增强假体感觉。
Artificial sensation via electrical or optical stimulation of brain sensory areas offers a promising treatment for sensory deficits. For a brain-machine-brain interface (BMBI), such artificial sensation conveys feedback signals from a sensorized prosthetic limb. The ways neural tissue can be stimulated to evoke artificial sensation and the parameter space of such stimulation, however, remain largely unexplored. Here we investigated whether stochastic facilitation (SF) could enhance an artificial tactile sensation produced by intracortical microstimulation (ICMS). Two rhesus monkeys learned to use a virtual hand, which they moved with a joystick, to explore virtual objects on a computer screen. They sought an object associated with a particular artificial texture (AT) signaled by a periodic ICMS pattern delivered to the primary somatosensory cortex (S1) through a pair of implanted electrodes. During each behavioral trial, aperiodic ICMS (i.e., noise) of randomly chosen amplitude was delivered to S1 through another electrode pair implanted 1 mm away from the site of AT delivery. Whereas high-amplitude noise worsened AT detection, moderate noise clearly improved the detection of weak signals, significantly raising the proportion of correct trials. These findings suggest that SF could be utilized to enhance prosthetic sensation.