Hemodynamic Effects of A Simplified Venturi Conduit for Fontan Circulation: A Pilot, In Silico Analysis
Hemodynamic Effects of A Simplified Venturi Conduit for Fontan Circulation: A Pilot, In Silico Analysis
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用于 Fontan 循环的简化文丘里导管的血流动力学效应：试点，计算机分析
DOI：
10.1038/s41598-020-57634-2
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发表时间：
2020-01
影响因子：
4.6
通讯作者：
Chen Huiwen
中科院分区：
文献类型：
--
作者：
Zhu Fang;Shi Guocheng;Wen Chen;Zhang Qian;Fu Qihua;Liu Jinlong;Zhu Zhongqun;Chen Huiwen
ObjectivesTo study the effects of a self-powered Fontan circulation in both idealized Fontan models and patient-specific models.MethodsIn silico, a conduit with a nozzle was introduced from ascending aorta into the anastomosis of superior vena cava and pulmonary artery. Computational fluid dynamics (CFD) simulation was applied to calculate the fluid fields of models. Three 3-dimentional idealized models with different offsets were reconstructed by computer-aided design to evaluate the effects of the self-powered conduit. Furthermore, to validate the effects in patient-specific models, the conduit was introduced to three reconstructed models with different offsets.ResultsThe pressures at superior venae cavae and inferior venae cavae were decreased in both idealized models (0.4 mmHg) and patient-specific models (0.7 mmHg). In idealized models, the flows to left lungs were decreased (70%) by the jets from the conduits. However, in patient-specific models, the reductions of blood to the left lungs were relatively limited (30%) comparing to idealized models.ConclusionsCFD simulation was applied to analyze the effectiveness of the Fontan self-powered conduit. This self-powered conduit may help to decrease the venae cavae pressures and increase the flow to pulmonary arteries.
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影响因子：
5.4
作者：
Laohachai K;Winlaw D;Selvadurai H;Gnanappa GK;d'Udekem Y;Celermajer D;Ayer J
通讯作者：
Ayer J
影响因子：
3.8
作者：
Restrepo M;Luffel M;Sebring J;Kanter K;Del Nido P;Veneziani A;Rossignac J;Yoganathan A
通讯作者：
Yoganathan A
影响因子：
1.8
作者：
Marcus W. Ni;Ray Prather;G. Rodriguez;Rachel E. Quinn;E. Divo;M. Fogel;A. Kassab;W. DeCampli
通讯作者：
Marcus W. Ni;Ray Prather;G. Rodriguez;Rachel E. Quinn;E. Divo;M. Fogel;A. Kassab;W. DeCampli
影响因子：
6
作者：
Whitehead, Kevin K.;Sundareswaran, Kartik S.;Parks, W. James;Harris, Matthew A.;Yoganathan, Ajit P.;Fogel, Mark A.
通讯作者：
Fogel, Mark A.
Fontan 手术：现代技术改善了长期结果
DOI：
10.1016/s0084-3873(08)79246-0
发表时间：
2008
期刊：
Yearbook of Medicine
影响因子：
--
作者：
T. Graham
通讯作者：
T. Graham