Direct Resolution of Isomeric and Diastereoisomeric Mixtures of Amides, Lactones, Alcohols, Carbazones and Pyrethenoid Derivatives
Direct Resolution of Isomeric and Diastereoisomeric Mixtures of Amides, Lactones, Alcohols, Carbazones and Pyrethenoid Derivatives
复制标题
直接拆分酰胺、内酯、醇、卡巴腙和拟除虫菊酯衍生物的同分异构和非对映异构混合物
DOI：
10.1080/01483918708066736
复制
发表时间：
1987
影响因子：
1.3
通讯作者：
D. Taylor
中科院分区：
文献类型：
--
作者：
J. Akanya;D. Taylor
摘要基于N-氨基酸衍生物的高效液相色谱手性固定相已实现了对多种不同功能性化合物的拆分。分离因子（α）为1.11-1.25。所研究的杀虫剂的醇衍生物未被解析成其对映体分子，然而此类溶质被解析成其非对映异构体。手性识别的机理是未来研究的主题。
Abstract The resolution of a wide range of compounds of different functionalities has been achieved by high performance liquid chromatography (HPLC) on chiral stationary phases based on N-formulated aminoacid derivatives. The separation factors (α) of 1.11–1.25 have been achieved. The alcohol derivatives of the insecticides investigated were not resolved into their enantiomeric molecules, however such solutes were resolved into their diastereoisomers. The mechanism of chiral recognition is a subject of future investigations.