Severe Japanese spotted fever successfully treated with fluoroquinolone
Severe Japanese spotted fever successfully treated with fluoroquinolone
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DOI：
10.2169/internalmedicine.45.1831
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发表时间：
2006-01-01
影响因子：
1.2
通讯作者：
Kohno, Shigeru
中科院分区：
文献类型：
--
作者：
Seki, Masafumi;Ikari, Naruhiko;Kohno, Shigeru
一位77岁的女性，因左臂被咬伤，出现焦痂，于5天前因高烧、严重不适、皮疹、意识障碍住进急诊病房。她被诊断为日本立克次体抗体阳性的日本斑点热，在证明盐酸米诺环素无效后，用氟喹诺酮治疗成功。从病人被叮咬的日本福冈山区采集的扁虱幼虫中，用聚合酶链式反应检测到日本立克线虫的特异性DNA。
A 77 years old woman who had a bite with eschar on her left arm, was admitted to emergency ward in our hospital, because of high fever, severe malaise, skin eruption, and consciousness disturbance beginning 5 days previously. She was diagnosed as Japanese spotted fever by seropositive of Rickettsia japonica (R. japonica) antibody, and successfully treated with fluoroquinolone, after minocycline hydrochloride had been proven ineffective. R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten.