DIET-INDUCED ADIPOCYTE NUMBER INCREASE IN ADULT RATS - NEW MODEL OF OBESITY
DIET-INDUCED ADIPOCYTE NUMBER INCREASE IN ADULT RATS - NEW MODEL OF OBESITY
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DOI：
10.1152/ajpendo.1978.235.3.e279
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发表时间：
1978-01-01
影响因子：
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通讯作者：
HIRSCH, J
中科院分区：
文献类型：
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作者：
FAUST, IM;JOHNSON, PR;HIRSCH, J
不同品系的成年大鼠在被喂食了几个月的美味食物后变得肥胖。他们的脂肪组织形态分析显示，在大多数仓库的脂肪细胞的大小和数量增加。对这些动物重新引入普通饲料会导致一段时间的体重减轻，在此期间，只有平均脂肪细胞大小恢复正常。脂肪细胞数量保持在体重增加期间达到的升高水平。大鼠一过性饮食性肥胖导致单纯增生性、非肥大性形式的持续性肥胖。细胞数量持续增加表明这是增殖或分化的结果，而不仅仅是非常小且通常未检测到的脂肪细胞池的脂质含量增加的结果。对饮食诱导的体重增加过程中脂肪组织形态变化的分析表明，达到某种特定的平均脂肪细胞大小触发了最终导致脂肪细胞数量增加的事件。脂肪细胞大小与新脂肪细胞形成之间的联系机制尚不清楚。
Adult rats of various strains became obese when they were fed a highly palatable diet for several months. Analysis of their adipose tissue morphology revealed increases in adipocyte size and number in most depots. Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of weight gain. Transient dietary obesity in rats resulted in a persistent obesity of a purely hyperplastic, nonhypertrophic form. The persistence of the cell number increase suggested that is was the result of proliferation or differentiation rather than of only an increase in the lipid content of a pool of very small and normally undetected adipocytes. An analysis of adipose tissue morphology changes during the course of diet-induced weight gain suggested that the achievement of some specific mean adipocyte size triggers the events that culminate in adipocyte number increase. What mechanisms may link adipocyte size to the formation of new adipocytes remains unknown.