Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder
Head circumference as an early predictor of autism symptoms in younger siblings of children with autism spectrum disorder
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DOI：
10.1007/s10803-007-0495-9
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发表时间：
2008-07-01
影响因子：
3.9
通讯作者：
Munson, Jeff
中科院分区：
文献类型：
--
作者：
Elder, Lauren M.;Dawson, Geraldine;Munson, Jeff
自闭症儿童的自闭症谱系障碍（ASD）的风险增加。由于自闭症儿童通常表现出头围（HC）增长的非典型轨迹，HC可能是自闭症易感性的指标。本研究调查了具有非典型HC生长轨迹的ASD儿童（n = 77）的婴儿兄弟姐妹是否比那些没有非典型HC轨迹的儿童更有可能出现自闭症症状。结果表明，在12个月时具有较大HC的婴儿，其HC生长速度在12至24个月之间减速更快，比具有更典型HC轨迹的婴儿更容易表现出自闭症症状。在自闭症儿童的婴儿兄弟姐妹中，非典型HC生长可能会提醒儿科医生提供筛查和/或转诊进行进一步评估。
Siblings of children with autism have an increased risk for autism spectrum disorders (ASD). As children with autism often exhibit an atypical trajectory of head circumference (HC) growth, HC may be an indicator of vulnerability to autism. This study investigated whether infant siblings of children with ASD (n = 77) with an atypical trajectory of HC growth were more likely than those without an atypical HC trajectory to develop autism symptoms. Results showed that infants who had larger HC at 12 months, and whose HC growth rate decelerated more rapidly between 12 and 24 months were more likely to exhibit autism symptoms than infants with more typical HC trajectories. Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation.