Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy
Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy
复制标题
用于癌症治疗的黑磷纳米结构智能近红外光控制药物释放的新概念
DOI：
10.1073/pnas.1714421115
复制
发表时间：
2018-01-16
影响因子：
11.1
通讯作者：
Cao, Yihai
中科院分区：
文献类型：
--
作者：
Qiu, Meng;Wang, Dou;Cao, Yihai
可生物降解的药物传递系统（DDS）是最有前途的肿瘤治疗策略之一。在这里，我们提出了一个独特的概念，光激活黑磷（BP）在水凝胶纳米结构的癌症治疗。光敏剂将光转化为热，其软化并熔化载药的基于水凝胶的纳米结构。药物释放速率可以通过光强度、暴露持续时间、BP浓度和水凝胶组成来精确控制。由于近红外（NIR）光足够深地穿透组织，我们的基于BP的系统显示出用于治疗皮下肿瘤的高治疗功效。癌的重要的是，我们的药物输送系统是完全无害的，在体内可降解。总之，我们的工作提出了一个独特的概念，通过外部光激发来释放癌症药物进行精确的癌症治疗。如果这些发现成功地转化为临床，数百万癌症患者将从我们的工作中受益。
A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.