Optimized synthesis of four isotopically labeled (13C-enriched) phenolic acids via a malonic acid condensation
Optimized synthesis of four isotopically labeled (13C-enriched) phenolic acids via a malonic acid condensation
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DOI：
10.1002/jlcr.869
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发表时间：
2004-10-15
影响因子：
1.8
通讯作者：
Schmidt, WF
中科院分区：
文献类型：
--
作者：
Robbins, RJ;Schmidt, WF
通过简单的一步丙二酸与一系列醛缩合，合成了四种同位素 (C-13) 标记的酚酸（咖啡酸 [M+3]、芥子酸 [M+2]、对香豆酸 [M+6] 和阿魏酸 [M+6] 酸）。醛和丙二酸被不同地标记和未标记，以改变富集位点。 13 C和(1)H NMR分析共同证实了标记位置。 LC/MS 确认了质量。这些酸旨在用作同位素稀释质谱 (IDMS) 的内标。版权所有 (C) 2004 John Wiley Sons, Ltd.
Four isotopically (C-13)-labeled phenolic acids (caffeic [M+3], sinapic [M+2], p-cournaric [M+6] and ferulic [M+6] acids) were synthesized via a simple one-step malonic acid condensation with a series of aldehydes. The aldehydes and the malonic acid were variously labeled and unlabeled to vary the enriched sites. 13 C and(1)H NMR analyses together confirmed the labeled positions. LC/MS confirmed the masses. These acids are intended for use as internal standards for isotope dilution mass spectrometry (IDMS). Copyright (C) 2004 John Wiley Sons, Ltd.