Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates.
Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates.
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DOI：
10.1039/c6cc05179k
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发表时间：
2016-08-16
期刊：
影响因子：
--
通讯作者：
Choi SK
中科院分区：
文献类型：
--
作者：
Wong PT;Tang S;Mukherjee J;Tang K;Gam K;Isham D;Murat C;Sun R;Baker JR;Choi SK
我们报道了一种基于光化学释放由靶向细胞壁的树枝状大分子纳米共轭物携带的光笼型环丙沙星的特异性靶向革兰氏阴性菌的主动递送机制。
我们报道了一种由靶向细胞壁的树枝状大分子纳米共轭物携带的光笼型环丙沙星的光控释放机制。这种靶向细菌策略的验证为现有的基于光的伤口治疗方法增添了一种新的模式。
We report an active delivery mechanism targeted specifically to Gram(−) bacteria based on the photochemical release of photocaged ciprofloxacin carried by a cell wall-targeted dendrimer nanoconjugate. We report a light-controlled release mechanism for photocaged ciprofloxacin carried by a cell wall-targeted dendrimer nanoconjugate. Validation of this bacteria-targeted strategy adds a novel modality to existing light-based therapies for wound treatments.