Human iodine requirements determined by the saturation kinetics model.
Human iodine requirements determined by the saturation kinetics model.
复制标题
人体碘需要量由饱和动力学模型确定。
DOI：
10.1016/s0955-2863(03)00034-2
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
L. Preston Mercer
中科院分区：
文献类型：
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作者：
Mohammed Hassanien;L. Hussein;Erica N Robinson;L. Preston Mercer
碘在新陈代谢以及大多数器官（尤其是大脑）的早期生长和发育过程中起着决定性作用。碘缺乏的影响包括甲状腺肿、死产和流产、新生儿和青少年甲状腺缺乏、侏儒症、精神缺陷、聋哑、痉挛性无力和瘫痪。在这项研究中，应用数学模型（源自 Machaelis-Menten 酶动力学）对从达赫拉绿洲埃及村庄 West El-Mawhoub 随机选择的一组尿液样本中测量的碘进行测量，得出的结论是，碘排泄参数可用于表征碘利用率，并准确预测维持正常生理功能所需的盐碘化水平。四参数饱和动力学模型分析表明，63 mg/kg 的盐碘化水平可降低 IDD 的严重程度，83% 的研究对象的尿排泄水平为 1.18 μmol/L。这提供了一种方便的机制，以非侵入性指数提供足够的膳食碘，以避免 IDD。使用标准碘量滴定方法分析市售盐以确定碘化水平。分析显示，只有 20% 的市售盐符合制造商的标签要求，并且批次之间存在较大的个体差异，达到声称的碘含量的 -95% 至 +150%。因此，盐加碘需要仔细监督，以确保交付和消耗承诺的碘水平。
Iodine plays a decisive role in metabolism and the process of early growth and development of most organs, especially of the brain. Effects of iodine deficiency include goiter, stillbirth and miscarriage, neonatal and juvenile thyroid deficiency, dwarfism, mental defects, deaf mutism, spastic weakness and paralysis. In this study, the application of a mathematical model (derived from Machaelis-Menten enzyme kinetics) to iodine measured in urine samples from a randomly selected group derived from the Egyptian village of West El-Mawhoub in the Dakhlah Oasis resulted in the conclusion that iodine excretion parameters can be used to characterize iodine utilization and accurately predict the level of salt iodination required to maintain proper physiological functions. The four parameter saturation kinetics model analysis indicated that a salt iodination level of 63 mg/kg reduced the severity of IDD, with 83% of the studied subjects having urinary excretion levels of 1.18 μmol/L. This gives a convenient mechanism for providing adequate dietary iodine with a non-invasive index for the avoidance of IDD. Commercially available salt was analyzed using standard iodiometric titration methods to determine iodination levels. Analysis revealed that only 20% of the commercially available salt complied with the manufacturer’s label and revealed the presence of large individual variability between batches amounting to −95 to +150% of the claimed iodine level. Therefore, salt iodination requires careful supervision to ensure that promised iodine levels are being delivered and consumed.