BRAIN SYSTEMS FOR ENCODING AND RETRIEVAL OF AUDITORY-VERBAL MEMORY - AN IN-VIVO STUDY IN HUMANS
BRAIN SYSTEMS FOR ENCODING AND RETRIEVAL OF AUDITORY-VERBAL MEMORY - AN IN-VIVO STUDY IN HUMANS
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DOI：
10.1093/brain/118.2.401
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发表时间：
1995-04-01
期刊：
影响因子：
14.5
通讯作者：
DOLAN, RJ
中科院分区：
文献类型：
--
作者：
FLETCHER, PC;FRITH, CD;DOLAN, RJ
在神经心理学水平上，长期非言语记忆包括许多不同的认知过程。在本研究中，我们确定的大脑系统参与编码（实验1）和提取（实验2）的情景记忆-言语材料。在单独的实验中，PET测量的局部脑血流量（rCBF），神经活动的指数，在编码或检索配对的单词联想正常志愿者进行。在实验1中，一个双任务干扰范式被用来隔离区参与情节编码从那些同时被激活的其他认知过程与配对联营公司的介绍，特别是启动。在实验2中，我们使用线索提取配对联想从情节或语义记忆，以分离的神经相关的情节记忆。情节记忆的编码与激活左前额叶皮层和扣带皮层的压后区相关，而情节记忆的提取与激活双侧楔前叶和右前额叶皮层相关。这些结果与先前PET记忆实验中同时研究编码和检索的激活模式相一致。他们还表明，在情景记忆-言语记忆的编码和提取阶段，不同的大脑系统参与其中。从情景记忆中提取的信息与从语义记忆中提取的信息所涉及的系统不同，但存在重叠，这一发现为这种神经心理学差异提供了功能解剖学支持。
Long-term auditory-verbal memory comprises, at a neuropsychological level, a number of distinct cognitive processes. In the present study we determined the brain systems engaged during encoding (experiment 1) and retrieval (experiment 2) of episodic auditory-verbal material. In the separate experiments, PET measurements of regional cerebral blood flow (rCBF), an index of neural activity, were performed in normal volunteers during either the encoding or the retrieval of paired word associates. In experiment 1, a dual task interference paradigm was used to isolate areas involved in episodic encoding from those which would be concurrently activated by other cognitive processes associated with the presentation of paired associates, notably priming. In experiment 2, we used the cued retrieval of paired associates from episodic or from semantic memory in order to isolate the neural correlates of episodic memories. Encoding of episodic memory was associated with activation of the left prefrontal cortex and the retrosplenial area of the cingulate cortex, while retrieval from episodic memory was associated with activation of the precuneus bilaterally and of the right prefrontal cortex. These results are compatible with the patterns of activation reported in a previous PET memory experiment in which encoding and retrieval were studied concurrently. They also indicate that separate brain systems are engaged during the encoding and retrieval phases of episodic auditory-verbal memory. Retrieval from episodic memory engages a different but overlapping, system to that engaged by retrieval from semantic memory, a finding that fends functional anatomical support to this neuropsychological distinction.