Effect of weight loss on serum lipoprotein(a) concentrations in an obese population.
Effect of weight loss on serum lipoprotein(a) concentrations in an obese population.
复制标题
减肥对肥胖人群血清脂蛋白（a）浓度的影响。
作者：
J. Corsetti;J. Sterry;J. Sparks;Charles E. Sparks;Michael Weintraub
为了评估肥胖人群中致动脉粥样硬化脂蛋白（a）[Lp（a）]血清浓度的分布以及体重减轻的可能影响，我们测定了52名白色中度肥胖受试者（16名男性和36名女性）的Lp（a）。受试者参加了减肥计划的饮食，运动，行为矫正加上组合厌食药物治疗（芬氟拉明和芬特明）。这项安慰剂对照的双盲研究持续了104周。我们还测定了空腹胰岛素、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、载脂蛋白（apo）A-I、低密度脂蛋白胆固醇和apo B的浓度。结果表明：肥胖人群中血清Lp（a）值的高度偏态、非高斯分布，与健康成人报告的几乎相同; Lp（a）浓度随体重减轻无临床显著变化;以及胰岛素、脂质和脂蛋白浓度随体重减轻正常化的进一步证据。
To assess the distribution of serum concentrations of the atherogenic lipoprotein(a) [Lp(a)] in an obese population and the possible effects of weight reduction, we determined Lp(a) in 52 white, moderately obese subjects (16 men and 36 women). The subjects were participating in a weight-reduction program of diet, exercise, and behavior modification plus combination anorectic drug therapy (fenfluramine and phentermine). This placebo-controlled, double-blind study lasted 104 weeks. We also determined concentrations of fasting insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein (apo) A-I, low-density lipoprotein cholesterol, and apo B. Results showed the following: a highly skewed, nongaussian distribution of serum Lp(a) values in the obese population, virtually identical to that reported for healthy adults; no clinically significant change in Lp(a) concentrations with weight loss; and further evidence of normalization of insulin, lipid, and lipoprotein concentrations with weight loss.
DOI：
10.1073/pnas.84.10.3224
发表时间：
1987-05-01
影响因子：
11.1
作者：
EATON, DL;FLESS, GM;SCANU, AM
通讯作者：
SCANU, AM
狒狒脂蛋白 (a) 的免疫化学表征和定量。
影响因子：
5.3
作者：
Rainwater,DL;Manis,GS
通讯作者：
Manis,GS